Parachlorophenylalanine (p-CPA) was used for chemical pinealectomy in a study of tail regeneration in the gekkonid lizard, Hemidactylus flaviviridis. Two doses of p-CPA (200 or 400 micrograms kg-1 body mass) were injected into two groups of lizards (5 days prior to and 30 days after caudal autotomy) exposed to continuous light of 2500 lx intensity during the summer season (March-May). Our obser...

Adult mammalian cardiomyocytes have little capacity to proliferate in response to injury, a deficiency that underlies the poor regenerative ability of human hearts after myocardial infarction. By contrast, zebrafish regenerate heart muscle after trauma by inducing proliferation of spared cardiomyocytes, providing a model for identifying manipulations that block or enhance these events. Although...

β-carotene, a natural antioxidant, beneficial form human health prospective. In this study we had examined the recovery of β-carotene form mesoporous carbon coated monolith (MCCM) by batch process. Desorption kinetics and isotherm studies were carried out by using nhexane as an eluent. Isotherm studies showed better applicability of Langmuir model. The first-order two-compartment three-paramete...

The curves of growth and of regeneration follow the same course, and can be represented by the same exponential equation. This is taken to substantiate the theory that growth and regeneration are essentially identical processes governed by the same laws. A common peculiarity of the curves of growth and of regeneration is that during a short period in the early stages of regeneration and of grow...

Molecular and cellular mechanisms underlying the peripheral conditioning lesion remain unsolved. We show here that injection of a chemical demyelinating agent, ethidium bromide, into the sciatic nerve induces a similar set of regeneration-associated genes and promotes a 2.7-fold greater extent of sensory axon regeneration in the spinal cord than sciatic nerve crush. We found that more severe pe...

Central nervous system (CNS) regeneration with central neuronal connections and restoration of synaptic connections has been a long-standing worldwide problem and, to date, no effective clinical therapies are widely accepted for CNS injuries. The limited regenerative capacity of the CNS results from the growth-inhibitory environment that impedes the regrowth of axons. Central neural tissue engi...

Demineralized bone matrix (DBM) is widely used for bone regeneration. Since DBM is prepared in powder form its handling properties are not optimal and limit the clinical use of this material. Various synthetic and biological carriers have been used to enhance the DBM handling. In this study we evaluated the effect of gamma irradiation on the physical-chemical properties of Pluronic and on bone ...

Phenotype-based small molecule screens in zebrafish embryos and larvae have been successful in accelerating pathway and therapeutic discovery for diverse biological processes. Yet, the application of chemical screens to adult physiologies has been relatively limited due to additional demands on cost, space, and labor associated with screens in adult animals. In this study, we present a 3D print...