Our previous work found that DMH1 (4-[6-(4-isopropoxyphenyl)pyrazolo [1,5-a]pyrimidin-3-yl]quinoline) was a novel autophagy inhibitor. Here, we aimed to investigate the effects of DMH1 on chemotherapeutic drug-induced autophagy as well as the efficacy of chemotherapeutic drugs in different cancer cells. We found that DMH1 inhibited tamoxifen- and cispcis-diaminedichloroplatinum (II) (CDDP)-indu...

A mathematical model of ordinary differential equations is considered to analyze the pharmacokinetics multi-chemotherapeutic drugs and their pharmacodynamic effects on homogeneous tumors. Set-valued analysis used design protocols drug administration applied decrease tumor density under carrying capacity Gompertz growth converge zero.

Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...

Paclitaxel is the one of the most common chemotherapeutic drugs used for the treatment of prostate cancer. However, its current clinical utility has been limited due to numerous serious side effects and drug resistance. Noscapine is an antitussive opium alkaloid that showed antitumor activity against a variety of cancer while has not exhibited severe side effects. This study investigates the a...

This paper analysis chemotherapy-induced peripheral neuropathy (CIPN) caused by related chemotherapeutic drugs and proposes some treatments from nursing intervention to drug treatment. It also calls for more efforts in the research of this field relieve psychological burden improve quality life patients at end paper.

The application of chemotherapy in cancer treatment has been limited due to cause side effects such as toxicity against normal cells and drug resistance. In recent years, numerous studies have been focused on using natural products with chemotherapeutic drugs to enhance therapeutic efficiency and reduce cytotoxicity. On the other hand, encapsulation of drugs into nanoparticles (NPs) can improve...

Nanotechnology has aimed to address limitations of new drug design by “repackaging” FDA approved drugs without compromising their therapeutic benefits while suppressing undesired side effects suffered patients undergoing chemotherapy. The major hurdles faced small molecular in treating cancer include hydrophobicity, rapid hepatic and renal clearance, short circulation time, off target toxicity ...

HIGHLIGHTS RT-qPCR efficiency can vary according to 260/280 ratio of samples analyzed. Chemotherapeutic drugs in the blood sample was not correlated with Ct variation (qPCR). The spectrophotometer determines a RNA quantification 2.2 times higher than fluorimeter. Antibiotics be associated 11.3% variability ratio.

Objective(s): Nanocarriers are drug delivery vehicles, which have attracted the attention of researchers in recent years, particularly in cancer treatment. The encapsulation of anticancer drugs using protein nanocages is considered to be an optimal approach to reducing drug side-effects and increasing the bioavailability of anticancer drugs. Epirubicin (EPR) is an active chemotherapeutic medica...