We examined the effects of two different drugs (cladribine and mitoxantrone), which are frequently used in chemotherapeutic treatment, on human serum paraoxanase1 (PON1) enzyme activity vitro. Chemotherapeutic decreased vitro PON1 activity. Cladribine mitoxantrone inhibition mechanism were not competitive inhibitors. IC50 values for cladribine calculated as 0.077 mM 0.099 mM, respectively, Ki c...

Progress in the field of cancer chemotherapy has been characterized recently by the development of broad screening programs for the assay of candidate therapeutic agents. A landmark in this field was the Gellhorn and Hirschberg [1] report on "Investigation of Diverse Systems for Cancer Chemotherapy Screening" which was devoted to an examination of a variety of biological systems potentially use...

Tuberculosis is the second leading cause of infectious deaths globally. Many effective conventional antimycobacterial drugs have been available, however, emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) has overshadowed the effectiveness of the current first and second line drugs. Further, currently available agents are complicated by s...

Cancer has emerged as a leading cause of death throughout the world. Peptides are a novel class of anticancer agents that can specifically target cancer cells with low toxicity to normal tissues and thus, offer new opportunities for future cancer treatment. On the other hand, Ciprofloxacin, an antibiotic, also known to its anticancer property for enabling cell cycle arrest and creating double s...

This fourth, thoroughly revised, edition of Calmette's well-known manual aims to bring together the maximum of information which will be of value to the bacteriologist in his daily work. It is based largely on the techniques utilized at the Pasteur Institute in Paris. The topics included differ from those found in similar manuals in this country which are usually texts of laboratory diagnosis a...

Chemotherapy may be indicated for the treatment of cancer during pregnancy. The decision to use chemotherapy significantly impacts the pregnancy, and in turn the pregnancy may affect the treatment options available to patients with cancer. This review provides information about the effects of chemotherapeutic agents in pregnancy, taking into account both the mother and the fetus. For convenienc...