Several chemotherapy regimens have been developed for the treatment of acute lymphoblastic leukemia (ALL), but relapse still presents the most common obstacles to attaining long-term survival. The hyper-CVAD (hyperfractionated cyclophosphamide, vincristine, doxorubicin, and prednisolone)/HD MTX and Ara-C (high-dose methotrexate and cytarabine) chemotherapy regimen was first started in the MD An...

elderly population. The subgroup analysis of the NSABP C-07 trial showed a trend towards better disease-free survival in patients younger than age 70 (hazard ratio, 0.80; 95% confidence interval, 0.68 to 0.95; P = 0.013), but no positive effect was evident in older patients with the addition of oxaliplatin to the FL regimen [10]. Even the NCCN guideline recommended that the oxaliplatinbased reg...

background: the induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. for patients with relapsed or refractory disease, alternative chemotherapy agents are available. monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozogami...

osteosarcoma may rarely originate from the axial bones such as pelvis or vertebrae. in some pelvic and most vertebral primary tumors, resection often is not possible completely. in general, these tumors cannot be resected with negative margins so they need additional radiotherapy and chemotherapy, but results are unfavourable because of poor local control and high incidence of distant metastase...

Peritoneal carcinomatosis is associated with poor prognosis in gastric cancer patients. Stage IV (GC) diagnosed 39.8 % of patients; local metastases without evidence distant occur only 18–20 stage The purpose the study was to estimate efficacy personalized chemotherapy combined modality treatment patients GC peritoneal carcinomatosis. Material and Methods. Cytoreductive surgery performed 70 dis...

Aim. The efficacy of the short hydration regimen was reported in chemotherapy containing intermediate- to high-dose cisplatin, and the use of outpatient chemotherapy containing cisplatin with short hydration has been widespread in recent years. Methods. We compared patients with gastric cancer, lung cancer, and urothelial cancer who received outpatient chemotherapy containing cisplatin (≥60 mg/...

PURPOSE This is the first study in which the NK(1)-receptor antagonist, aprepitant (APR), was evaluated for the prevention of chemotherapy-induced nausea and vomiting (CINV) with moderately emetogenic chemotherapy. PATIENTS AND METHODS Eligible breast cancer patients were naive to emetogenic chemotherapy and treated with cyclophosphamide +/- doxorubicin or epirubicin. Patients were randomly a...

PURPOSE There is no effective treatment for patients with advanced gastric cancer having failed to respond to first line chemotherapy. The aim of this study was to evaluate the therapeutic activity, and safety, of a FEP regimen in patients with a recurrence of, or metastatic, gastric cancer that had been unresponsive to primary chemotherapy. MATERIALS AND METHODS Recurred or metastatic gastri...

OBJECTIVE To assess the efficacy of primary chemotherapy in patients with clinically staged Hodgkin's disease. DESIGN Non randomized study. SETTING Pediatric Oncology Division of Regional Cancer Center. SUBJECTS Twenty nine children with Hodgkin's disease. INTERVENTIONS Chemotherapy was given to 21 patients whose parents agreed for the same. Sixteen children received COPP regimen and 5 ...

Primary colonic lymphoma is a very rare malignant tumor with no standard treatment. We report two cases of primary successfully treated surgery and chemotherapy, chemotherapy alone, respectively. The first case was 61-year-old woman who presented abdominal pain more than 1 month. patient diagnosed tumor, immunohistochemical examinations confirmed the initial diagnosis lymphoma. underwent laparo...