Capillary electrophoresis has matured into a highly sensitive and widely applied analytical method over the last forty years. Here we combine text mining computational chemistry to paint, with very broad strokes, applicability trends in scientific literature on capillary electrophoresis, simultaneously demonstrating that this is not only possible, but reveal both expected unexpected details of ...

We present a compact portable chip-based capillary electrophoresis system that employs capacitively coupled contactless conductivity detection (CD) operating at 4 MHz as an alternative detection method compared to the commonly used optical detection employing laser-induced fluorescence. The disposable chip for this system is fabricated out of PMMA using injection molding; the electrodes are scr...

A monolithic capillary electrophoresis system with integrated on-chip fluorescence detector has been microfabricated on a silicon substrate. Photodiodes in the silicon substrate measure fluorescence emitted from eluting molecules. The device incorporates an on-chip thin-film interference filter that prevents excitation light from inhibiting the fluorescence detection. A transparent AZO conducti...

Sorting and sizing of DNA molecules by capillary electrophoresis (CE) within the human genome project have enabled the genetic mapping of various illnesses. By the use of miniaturized lab-on-achip devices, on-chip-integrated DNA sequencing and genetic diagnostics have become feasible. The inherent advantages of microfluidic CE separation of differently sized DNA molecules, high-speed operation ...

A monolithic capillary electrophoresis system with integrated on-chip fluorescence detection has been microfabricated on a silicon substrate. Photodiodes in the silicon substrate measure fluorescence emitted from eluting molecules. An on-chip thin film interference filter prevents excitation light from inhibiting the fluorescence detection. A transparent conducting ground plane prevents the hig...

Femtosecond-laser-written optical waveguides were monolithically integrated into a commercial lab-on-a-chip to intersect a microfluidic channel. Laser excitation through these waveguides confines the excitation window to a width of 12 μm, enabling high-spatial-resolution monitoring of different fluorescent analytes, during their migration/separation in the microfluidic channel by capillary elec...

An efficient, nanoliter-scale microfabricated bioprocessor integrating all three Sanger sequencing steps, thermal cycling, sample purification, and capillary electrophoresis, has been developed and evaluated. Hybrid glass-polydimethylsiloxane (PDMS) wafer-scale construction is used to combine 250-nl reactors, affinity-capture purification chambers, high-performance capillary electrophoresis cha...