The study of optically active polymers is a very active research field, and these materials have exhibited a number of interesting properties. Much of the attention in chiral polymers results from the potential of these materials for several specialized utilizations that are chiral matrices for asymmetric synthesis, chiral stationary phases for the separation of racemic mixtures, synthetic mole...

Separation of the enantiomers of linezolid has been compared on derivatized cellulose and amylose chiral stationary phases (Chiracel OD and Chiralpak AD) with mixtures of hexane with 1-propanol, 2-propanol, or ethanol as mobile phases. It was found that use of a small amount of water as mobile phase additive can improve or prevent enantioseparation, depending on the column. The order of elution...

The interconverting stereoisomers of tri-o-thymotide have been separated by HPLC on chiral stationary phases and the temperature dependence of the dynamic chromatographic patterns has been interpreted in terms of exchange between enantiomeric propeller and helical conformations. Computed low energy structures and CD spectra were used in absolute configuration assignment.

A set of 42 chiral compounds containing stereogenic sulfur was prepared. There were 31 chiral sulfoxide compounds, three tosylated sulfilimines and eight sulfinate esters. The separations were done using five different macrocyclic glycopeptide chiral stationary phases (CSPs), namely ristocetin A, teicoplanin, teicoplanin aglycone (TAG), vancomycin and vancomycin aglycone (VAG) and seven eluents...

Polysaccharides, such as cellulose and amylose, are abundant and optically active carbohydrate-based resources. Their suitably modified derivatives (for example, benzoate and phenylcarbamate derivatives) exhibit excellent resolution abilities for a wide variety of chiral compounds when applied to chiral stationary phases (CSPs) for high-performance liquid chromatography. Despite the established...

In this study, brush type and polymer stationary phases were prepared based on (S)-N-(1-phenylethyl) acrylamide, the polymeric phase demonstrated superior chiral recognition ability. The two synthesized by strategies, one was “grafting from” method, which obtained CSP initiating monomer polymerization surface of 3-methacrylatepropyl silica gel, other to”, fixed copolymer acrylamide trimethoxysi...