OBJECTIVES This study evaluated the antibacterial effect and mechanical properties of composite resins (LCR, MCR, HCR) incorporating chitosan with three different molecular weights (L, Low; M, Medium; H, High). MATERIALS AND METHODS Streptococcus (S). mutans 100 mL and each chitosan powder were inoculated in sterilized 10 mL Brain-Heart Infusion (BHI) solution, and was centrifuged for 12 hr. ...

This study examines substances from plant leaves of Azadirachta indica and Melia azedarach extracted with methanol (80%) then successively fractionated increasing gradient polarity solvents. The extract the two was selected to be incorporated nanocomposites because their high antimicrobial activities. HPLC analysis performed for determination total phenolics flavonoids. LC–ESI–MS positive ion a...

• Liposomes with chlorhexidine (CHX) were incorporated into chitosan hydrogel. CHX-liposomes-in-chitosan hydrogel significantly reduced inflammatory response. inhibited biofilm formation. S. aureus and P. aeruginosa biofilms. Successful treatment of skin infections requires eradication biofilms found in up to 90 % all chronic wounds, causing delayed healing increased morbidity. We hypothesized ...

Chitosan (CH) is a biopolymer that exhibits a number of interesting properties such as anti-inflammatory and antibacterial activity and is also a promising platform for the incorporation of photosensitizing agents. This study aimed to evaluate the efficacy of antimicrobial activity of chitosan hydrogel formulation alone and in combination with the methylene blue (MB) associated with antimicrobi...

A novel bio nanocomposite of Carboxymethyl Starch (CMS)-Chitosan (CS)-Montmorillonite (MMT) was developed for Curcumin delivery. To improve Curcumin entrapment into Cs-CMS-MMT, different ratios of Chitosan (Cs), Carboxymethyl Starch (CMS) and MMT were used. Particle size and Curcumin entrapment efficiency (EE) were highly affected by different formulation variables. Polysaccharide concentration...

Titania nanotube-based local drug delivery is an attractive strategy for combating implant-associated infection. In our previous study, we demonstrated that the gentamicin-loaded nanotubes could dramatically inhibit bacterial adhesion and biofilm formation on implant surfaces. Considering the overuse of antibiotics may lead to the evolution of antibiotic-resistant bacteria, we synthesized a new...

Background: Pseudomonas aeruginosa biofilm is one of the problems in antibiotic treatment infections. Nanomedicines, such as chitosan (CS) can carry multiple drugs and improve therapeutic effects antibiotics. Objectives: This study aimed at synthesis characterization ciprofloxacin-loaded nanoparticles for eradication P. aeroginosa biofilm. Methods: Cipro-CS microparticles were prepared by ionic...

Chitosan derivatives substituted with benzophenone groups that can be cross-linked by ultraviolet light were synthesized as coatings for PEEK substrates used in the construction of lumbar cages. The IC90 values benzophenone-modified chitosan polymers solution before crosslinking same range those reported native chitosan. resulting hydrogel surface after exhibited excellent antimicrobial propert...