The influence of nitric oxide (NO) on hypnotic activity of diazepam, chlordiazepoxide and clonazepam was studied in mice. Administration of both non-selective NO synthase inhibitors: N(G)-nitro-L-arginine methyl ester (L-NAME), N(G)-nitro-L-arginine (L-NOARG) and selective NO synthase inhibitor 7-nitroindazole (7-NI) resulted in significant increase in the duration of diazepam-, chlordiazepoxid...

The authors applied Contol (Chlordiazepoxide) to 26 cases of the patients complained of vertigo. It was effective in 11 cases, gave some relief of the complaint in 9 cases, but was ineffective in 6 cases. In this study, Contol was found to be effective largely in those cases with chief complaints of dizziness and heavy head which were considered to be functional and reversible and of retro-laby...

Patients suffering from alcohol withdrawal were found on initial audit to be discharged before the resolution of their symptoms. A regimen using symptom triggered chlordiazepoxide was introduced and found, on re-audit and anecdotally, to be an improvement. The duration of symptoms was reduced significantly, the length of stay was reduced (although not statistically significant because of limite...

Lofexidine is an alpha-adrenoceptor agonist which has proved useful in opiate withdrawal and which, through its attenuation of noradrenergic activity, might be a valuable adjunct in the management of alcohol withdrawal. The objective of this study was to compare the clinical effectiveness and patient retention with adjunctive lofexidine versus placebo in the treatment of alcohol withdrawal unde...

We report a fluorometric method for detecting diazepam, chlordiazepoxide, oxazepam, chlorazepate, and (or) their major metabolites in blood, urine, or gastric contents at low therapeutic concentrations. The drugs are first hydrolyzed to their respective benzophenones and converted to highly fluorescent 9-acridanones. Total benzodiazepines (parent plus metabolites) in blood and gastric contents ...