The endocannabinoid 2-arachidonoylglycerol (2-AG) plays a major role in many physiological processes, and its action is quickly terminated via enzymatic hydrolysis catalyzed by monoglyceride lipase (MGL). Regulating its endogenous level could offer therapeutic opportunities; however, few selective MGL inhibitors have been described so far. Here, we describe the synthesis of N-substituted maleim...

Carbohydrate-protein interactions govern many crucial processes in biological systems including cell recognition events. We have used the sensitive force probe optical tweezers to quantify the interactions occurring between MGL lectins and MUC1 carrying the cancer-associated glycan antigens mucins Tn and STn. Unbinding forces of 7.6 pN and 7.1 pN were determined for the MUC1(Tn)-MGL and MUC1(ST...

Mg deficiency is considered as a risk factor of cardiovascular disorders like hypertension and atherosclerosis. MGH and MGL mice, selected for high and low Mg status, are animal models which present variations of Mg metabolism of genetic origin. The cardiovascular functions of these mice have never been studied. In this study, the arterial blood pressure of MGH and MGL strains was measured by p...

Endocannabinoids function as retrograde messengers and modulate synaptic transmission through presynaptic cannabinoid CB1 receptors. The magnitude and time course of endocannabinoid signaling are thought to depend on the balance between the production and degradation of endocannabinoids. The major endocannabinoid 2-arachidonoylglycerol (2-AG) is hydrolyzed by monoacylglycerol lipase (MGL), whic...

Adult-onset Still's disease (AOSD) is a multisystem inflammatory disease of unknown etiology. It is characterized by arthritis, hectic fever, transient rash and visceral lesions such as pleuropericarditis, lymphadenopathy and hepato splenomegaly. Although kidney involvement may appear in some cases of AOSD, minimal glomerular lesion (MGL) has not been described. We describe a female patient, wh...

C-type lectin receptors (CLRs) on antigen-presenting cells (APCs) facilitate uptake of carbohydrate antigens for antigen presentation, modulating the immune response in infection, homeostasis, autoimmunity, allergy, and cancer. In this review, we focus on the role of the macrophage galactose type C-type lectin (MGL) in the immune response against self-antigens, pathogens, and tumor associated a...

An in vitro method was developed for high frequency shoot regeneration and continuous production of Brassica napus L. in large number. The different concentrations of benzyladenine (1.5, 3.0 and 4.5 mgl and thidiazuron (0, 0.15 and 0.30 mgl) were evaluated for shoot and root regeneration using hypocotyl explants with 7, 14 and 21 days old. Shoot regeneration (SR) was affected by both benzyladen...

5-aminolevulinic acid (ALA) is an important plant growth regulator which derived from 5-carbon aliphatic amino acid. Here, ALA was examined in 12 dSm-1 salinity and biochemical changes mustard (Brassica juncea L. cv. BARI Sarisha-16) seedlings. Three NaCl mediated levels (0, 8 dS m-1) were used with two concentrations (30 60 mgL-1). Saline stress decreased height, root length, leaf area, dry ma...

Mrs. Gerber’s Lemma (MGL) hinges on the convexity of H(p ∗ H(u)), where H(u) is the binary entropy function. In this work, we prove thatH(p∗f(u)) is convex in u for every p ∈ [0, 1] provided H(f(u)) is convex in u, where f(u) : (a, b) → [0, 1 2 ]. Moreover, our result subsumes MGL and simplifies the original proof. We show that the generalized MGL can be applied in binary broadcast channel to s...