Intraperitoneal administration of the synthetic octapeptide of cholecystokinin, but not of secretin, produced rapid, large, dose-related, transient, and behaviorally specific inhibitions of solid and liquid food intake at test meals in rats without evidence of side effects or illness. Cholecystokinin may play an inhibitory role in the short-term control of feeding behavior. [The SCI indicates t...

ISENBERG, JON I., AND ATTILA CSENDES. Efect of octapeptide of cholecystokinin on canine pyloric pressure. Am. J. Physiol. 222(2) : 42843 1. 1972.-Intraluminal pressure was measured in five dogs with gastric and duodenal cannulas. Open-tipped perfused tubes were used as pressure sensors. To localize the pylorus (i.e., gastroduodenal junction), transluminal potential difference was recorded. The ...

Kosaka and Lim (1930) demonstrated that extracts from the upper intestine would inhibit gastric secretion from dogs with Heidenhain pouches. The degree of inhibition produced was similar to that observed after the oral ingestion of fat. Similar doses of the extract were shown to have no effect on either pancreatic or biliary secretion. Gillespie and Grossman (1964) have demonstrated that cholec...

Agonist-induced changes in cytoplasmic free Ca2+ concentration [( Ca2+]i) of isolated canine gastric chief cells were evaluated by microspectrofluorometry of superfused fura-2 loaded cells. Application of high concentrations of carbachol (CCh, 10(-5) M) or cholecystokinin octapeptide (10(-8) M) resulted in biphasic Ca2+ mobilization comprising an initial large transient followed by a small sust...

The lower respiratory tract of the sheep was studied by light-microscopical immunocytochemistry for serotonin, cholecystokinin, somatostatin, bombesin and calcitonin during different periods of lung development; embryonic, foetal and postnatal. At embryonic period only intraepithelial serotonin-containing cells as solitary neuroendocrine cells (NEC) and neuroepithelial bodies (NEB) were found. ...