Neroe endings and deposits of cholinesterase were stained in frozen sections of five normal striated human eye muscles with a stain that combines the neroe fiber techniijue of Hortega and the method of Koelle and Friedenwald for the demonstration of cholinesterase. Cholinesterase deposits are found at the base of the motor end plates. Dense cholinesterase deposits can also he found around thin ...

The inhibition of cholinesterase (ChE) and related enzymes, by organophosphorus compounds, is generally believed to occur by direct phosphorylation of some group at the active centre of the enzyme, together with the liberation of an acid anion (Wilson, 1951; Balls & Jansen, 1952; Hartley & Kilby, 1952; Aldridge, 1954; Kilby & Youatt, 1954). Inhibition by organophosphorus compounds is generally ...

Oximes (with or without atropine as an adjunct) have recently been used successfully in the treatment of humans poisoned by organophosphate anticholinesterases. The discovery of the nature of the biochemical lesion in organophosphate poisoning has permitted the design of drugs to repair specifically this particular lesion. This paper reviews historically the researches which led to the developm...

Acetylcholinesterase has important role in synaptic cleft. It breaks down the acetylcholineatcholinergic synapsesand terminates the cholinergic effects. Some chemical agents likeorganophosphorus compounds (OPCs) including nerve agents and pesticides react withacetylcholinesteraseirreversibly. They inhibit normal biological enzyme action and resultin accumulation of acetylcholineand show toxic e...

Cholinesterase inhibitors are the 'first-line' agents in the treatment of Alzheimer's disease. This article presents the latest information on their pharmacokinetic properties and pharmacodynamic activity. Tacrine was the first cholinesterase inhibitor approved by regulatory agencies, followed by donepezil, rivastigmine and recently galantamine. With the exception of low doses of tacrine, the c...

schizophrenia and various neurological disorders have some signs and symptoms. visual hallucinations are one of such disorders. the related studies in some diseases for example parkinson disease and lewy body dementia indicate that acetylcholine (ach) plays a significant role in neuropsychiatric manifestation and its association with visual hallucination; therefore, visual hallucinations occur ...

2-Isopropyl-4-dimethylamino-5-methylphenyl-1-piperidine carboxylate methyl chloride (AMO-1618) inhibits the activity of a cholinesterase isolated from mung bean (Phaseolus aureus) roots at concentrations comparable to those which retard growth and inhibit development of secondary roots of bean seedlings. Fifty per cent inhibition of the cholinesterase activity occurred at 0.21 mm. Inhibition of...

Cholinesterase Activity in Female Greenhouse Workers—Influence of Work Practices and Use of Oral Contraceptives: Jesper B NIELSEN, et al. Environmental Medicine, University of Southern Denmark—Objectives—Associations between serum butyryl cholinesterase activity in female greenhouse workers and information from a questionnaire on work, use of personal protective equipment, and lifestyle were ev...