In order to determine whether the developing central gustatory system responds to dietary manipulation during restricted developmental periods, terminal fields of the chorda tympani nerve within the nucleus of the solitary tract were investigated via anterograde transport of horseradish peroxidase in control rats and in rats in which a low sodium diet was systematically fed during specific peri...

To test whether undissociated acid is capable of exciting the chorda tympani nerves in rats, we have used buffered acid solutions as taste stimuli. These solutions were prepared by adding alkali to weak acids, such as acetic acid, so that the proportion of undissociated and dissociated acids was varied whereas keeping the total acid concentration constant. When acetic acid solutions, adjusted t...

We studied the effects of cold ambient temperature on chorda tympani nerve responses to taste stimuli such as sucrose, NaCl, quinine HCl (QHCl), and HCl in rats. The electrophysiological recordings of the whole chorda tympani nerves from control (22°C) and cold-exposed (4°C) rats revealed that the responses to sucrose, HCl, and QHCl were unaffected by cold exposure. In contrast, the nerve respo...

The M mode and two dimensional echocardiographic and the left ventricular end diastolic pressure was abnormalities of ruptured chorda tendinae of the mitral 18 mm Hg. Left ventricular angiography showed a dilated valve leaflets in non-rheumatic mitral valve disease have left ventricle with good contraction and severe grade IV been well documented.' 2 Echocardiographic abnormalities mitral regur...

The author studied anatomical variations of the origin of the chorda tympani nerve from the mastoid portion of the facial nerve. The studies were performed on 200 specimens of human temporal bone. It was found that the chorda tympani may arise from the facial nerve in three levels: most commonly from the mid third of its mastoid segment (70%), less commonly from the proximal third (20%), an...

The gross morphology of the tongue of the Mongolian gerbil Meriones unguiculatus), the location of papillae and taste buds, and the normal innervation pattern of the tongue and taste buds were determined. The chorda tympani nerve was interrupted to produce degeneration of fungiform taste buds. Regenerating chorda tympani axons followed the original nerve pathways in the tongue en route to the f...

Brain-derived neurotrophic factor (BDNF) is expressed in gustatory epithelia and is required for gustatory neurons to locate and innervate their correct target during development. When BDNF is overexpressed throughout the lingual epithelium, beginning embryonically, chorda tympani fibers are misdirected and innervate inappropriate targets, leading to a loss of taste buds. The remaining taste bu...

BACKGROUND The polycystic kidney disease-like ion channel PKD2L1 and its associated partner PKD1L3 are potential candidates for sour taste receptors. PKD2L1 is expressed in type III taste cells that respond to sour stimuli and genetic elimination of cells expressing PKD2L1 substantially reduces chorda tympani nerve responses to sour taste stimuli. However, the contribution of PKD2L1 and PKD1L3 ...

Chorda tympani nerve transection (CTX) has been useful to study the relationship between nerve and taste buds in fungiform papillae. This work demonstrated that the morphological integrity of taste buds depends on their innervation. Considerable research focused on the effects of CTX on peripheral gustatory structures, but much less research has focused on the central effects. Here, we explored...