OBJECTIVE Chorea is characterized by involuntary, fleeting, irregular, nonrhythmic movements that flow from 1 body region to another. There are many causes of childhood chorea, including cerebrovascular accidents, collagen vascular diseases, drug intoxication, hyperthyroidism, Wilson's disease, Huntington's disease, and infectious agents. Although Sydenham's chorea (SC), a nonsuppurative sequel...

OBJECTIVES To establish the effect of the atypical neuroleptic clozapine on chorea, voluntary motor performance, and functional disability in patients with Huntington's disease. METHODS Thirty three patients with Huntington's disease participated in a double blind randomised trial. A maximum of 150 mg/day clozapine or placebo equivalent was given for a period of 31 days. Assessments were perf...

Chorea-the term itself is a rather peculiar one. The word chorea is derived from the Greek word for dance and originally was applied to describe the dancelike gait of the dancing mania, a hysterical disorder of the late Middle Ages. The term is now used to describe an entire class of abnormal spontaneous movements. Each of these movements is a single, isolated muscle action: a short, rapid , un...

OBJECTIVES Mutations in GNAO1 have been described in 11 patients to date. Although most of these individuals had epileptic encephalopathy, four patients had a severe movement disorder as the prominent feature. We describe the largest series of patients with de novoGNAO1 mutations who have severe chorea, developmental delay, and hypotonia in the absence of epilepsy. METHODS Six patients with r...

INTRODUCTION Tetrabenazine (TBZ) reduces chorea related to Huntington disease (HD); however, it is uncertain whether this effect improves functionally relevant motor skills such as hand coordination and balance. The objective of this study was to provide pilot data regarding three motor function tests, which might be useful in monitoring symptom progression and therapeutic response, pending for...

roleptic drugs. She had no family history of movement disorders. On admission, she had chorea involving the left arm and leg. The chorea was continuous and could not be suppressed voluntarily, although it disappeared during sleep. It gradually worsened over the following days, involving the left face, left arm, left leg, and the right leg to a lesser degree. The patient also showed frequent, re...

BACKGROUND Chorea, hemichorea-hemiballismus and severe partial seizures may be the presenting feature of nonketotic hyperglycemia in older adults with type 2 diabetes, but cases in children with type 1 diabetes are rare, since the most easily recognized symptoms of type 1 diabetes in children are secondary to hyperglycemia, glycosuria, and ketoacidosis. CASE PRESENTATION A previously healthy ...

Chorea of subacute onset is a movement disorder that typically has monophasic course. can be associated with autoimmune diseases such as antiphospholipid syndrome and been the isolated presence antibodies (aPL). Here, we report patient aPL-related chorea unusually followed relapsing-remitting A female in her forties developed gravidarum during first pregnancy, eight years previously, again seco...

A case of primary polycythaemia presenting with severe chorea is reported and compared with previous cases. The aetiological factors of the chorea are discussed and the importance of early diagnosis stressed.

The habituation index is a quantitative expression of the ability of the orbicularis oculi (blink reflex) to adapt to a series of electrical stimuli applied to the supraorbital region. This parameter has been studied in a group of normal control subjects, and the results compared with those in cases of idiopathic and drug-induced Parkinsonism, states of dementia, and dyskinesias such as Hunting...