Choriocarcinoma, a malignancy of trophoblastic cells, is characterized by the secretion of human chorionic gonadotropin (hCG). Choriocarcinoma primarily arises from the fetal (placental) trophoblasts in the setting of a molar pregnancy. Nongestational choriocarcinoma from the ovary or testis is much rarer. Testicular choriocarcinoma is a malignant tumor with great propensity for distant metasta...

RATIONALE Rare uterine choriocarcinoma can be differentiated gestational from nongestational choriocarcinoma by using short tandem repeats (STRs). PATIENT CONCERNS A 56-year-old Taiwanese woman underwent staging surgery because of suspicion of high-grade endometrial cancer. The pathology-confirmed uterine tumor with syncytiotrophoblasts and decidual change of the endometrium was harvested. ...

Note Choriocarcinoma of the ovary is a highly malignant ovarian tumor which is characterized pathologically by the presence of trophoblastic malignant cells, and biochemically by the production of the pregnancy hormone human chorionic gonadotrophin (hCG) in the absence of an ongoing pregnancy. Choriocarcinoma tends to be invasive and to metastasize early and widely through both the venous and l...

Choriocarcinoma is part of the spectrum of gestational trophoblastic disease that occurs in women of reproductive age. Although the most common metastatic site of choriocarcinoma is the lung, primary pulmonary choriocarcinoma is rare. To diagnose primary pulmonary choriocarcinoma, the patient should have no previous gynecologic malignancy, have elevated human chorionic gonadotropin, and have pa...

A 42-year-old woman with choriocarcinoma required emergency pulmonary embolectomy under cardiopulmonary bypass. After diagnosis of choriocarcinoma was confirmed by examination of tumor emboli specimens, the patient was treated and had complete remission by chemotherapy over a 6-month period. Although rare, choriocarcinoma should be considered in the differential diagnosis of fertile women prese...

•We report on the medical treatment and outcomes of choriocarcinoma in Hispanic postmenopausal women.•A diagnosis of choriocarcinoma should be considered in older women with elevated serum β-hCG levels.•The unadjusted incidence of choriocarcinoma was calculated using data from the Texas Cancer Registry.

Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational choriocarcinoma of the ovary is extremely rare, and its diagnosis is very difficult during the reproductive years. We present a case of a 33-year-old woman diagnosed with pure nongestational ovarian choriocarcinoma. Following surgery, multiple courses of a chemotherapy regimen of etoposide, methotrexate,...

BACKGROUND Primary non-gestational uterine cervical choriocarcinoma is very unusual and although it has been hypothesized that it can arise by metaplastic transformation of cervical epithelium, solid evidence has been lacking. CASE Primary non-gestational uterine cervical choriocarcinoma was diagnosed in a 47-year-old, woman undergoing tubal resection 17 years previously. A histologically- an...

Background: Chorionic carcinoma is a highly malignant gynecological tumor, frequently originating from trophoblastic cells in the uterus after fertilization. Early erosion releases cancerous cells into the circulation to invade surrounding organs without primary symptoms and signs. Methods: One case of choriocarcinoma sellar region metastasis was analyzed, utilizing clinical data, MRI and patho...