Balanced and accurate information about Down's syndrome. The fact that screening does not give a definite diagnosis. An explanation of the risk score obtained following screening. The screening pathway and next steps for screen-positive and screen-negative results, including information about the decisions that need to be made at each step and their consequences. Information about amniocentesis...

INTRODUCTION The aim of this study was to examine the potential effect of chorionic villus sampling (CVS) on placental perfusion by examining the change in uterine artery pulsatility index (PI) between the first and second trimesters of pregnancy. MATERIALS AND METHODS This was a prospective screening study for pregnancy complications which included measurement of uterine artery PI at 11(+0) ...

BACKGROUND A major disadvantage of second trimester amniocentesis is that the result is usually available only after 18 weeks' gestation. Chorionic villus sampling (CVS) and early amniocentesis can be done between 9 and 14 weeks and offer an earlier alternative. OBJECTIVES The objective was to assess comparative safety and accuracy of second trimester amniocentesis, early amniocentesis, trans...

Cederholm, M. 2002. Consequences of amniocentesis and chorionic villus sampling for prenatal diagnosis. Acta Universitatis Upsaliensis. Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine 1118, 43 pp. Uppsala. ISBN 91554-5225-6. Amniocentesis (AC) and chorionic villus sampling (CVS) are the principal methods for fetal karyotyping. The aim of this thesis was to evaluate...

BACKGROUND A significant number of pregnancies are associated with the cytogenetic abnormalities of the fetus. Amniocentesis and chorionic villus sampling (CVS) are procedures used for prenatal genetic diagnosis. In this study, we compare the safety and complications of mid-trimester amniocentesis and transabdominal CVS. MATERIALS AND METHODS This analytic cross-sectional study was performed ...

Chorionic villi samples are widely used for prenatal diagnosis of various fetal disorders. Although, our knowledge regarding the molecular level of these disorders is extensive, little is known about the implicated proteins. In the present study, two dimensional electrophoresis (2-DE) followed by mass spectrometry (MS) was applied to reveal the proteomic profile of the CV cells. This proteomic ...