1. Lignocaine readily passes from blood into cerebrospinal fluid. The isolated rabbit choroid plexus, a locus of the blood-cerebrospinal fluid barrier, accumulated [14C]lignocaine by two processess: an active, saturable transport process and a non-saturable process. 2. The accumulation of [14C]lignocaine by choroid plexus was not due to non-specific binding or metabolism of lignocaine within or...

background: previous studies have shown that morphine consumption during pregnancy may cause delay or defect of embryo development or abnormal nervous system function in the human and animal models. in the present study, the highest density of morphine accumulation in the central nervous system of rat embryos was evaluated using c14‑morphine. methods: female wistar rats (w 170‑200 g) used and w...

The choroid plexus epithelium of the brain ventricular system produces the majority of the cerebrospinal fluid and thereby defines the ionic composition of the interstitial fluid in the brain. The transepithelial movement of Na+ and water in the choroid plexus depend on a yet-unidentified basolateral stilbene-sensitive Na+-HCO3- uptake protein. Reverse transcriptase-polymerase chain reaction (R...

BACKGROUND AND PURPOSE Postoperative contrast-enhanced MR imaging of the brain is routinely used when evaluating for residual or recurrent brain tumor. It is imperative to be aware of morphologic changes and imaging features that typically occur in response to surgical manipulation at the postoperative site to avoid misinterpretation of imaging findings. Our purpose was to determine normal post...

The choroid plexus epithelium is a cuboidal cell monolayer, which produces the majority of the cerebrospinal fluid. The concerted action of a variety of integral membrane proteins mediates the transepithelial movement of solutes and water across the epithelium. Secretion by the choroid plexus is characterized by an extremely high rate and by the unusual cellular polarization of well-known epith...

The relative levels of expression of Na,K-ATPase a and j3 subunit isoforms were determined in rat cerebral microvessels, choroid plexus, and capillary-depleted brain homogenates by Western blot analysis. Three a (al, a2, as) and two j3 vl, B2) subunits were detected in brain as previously reported. All 3 a and 2 j3 isoforms were also found in microvessels. The choroid plexus expressed al, fll, ...