diosmin and hesperidin are natural flavonoid glycosides found in various plant materials, mainly in citrus fruits in different concentrations. diosmin for pharmaceutical use is obtained mainly semi-synthetically from hesperidin. hesperidin often accompanies diosmin as a natural impurity in different pharmaceutical formulations; therefore, a simple, fast and precise method for the simultaneous a...

This work describes a comparative qualitative and quantitative chemical analysis of Maytenus ilicifolia and Maytenus robusta (Celastraceae), extracts by high-resolution gas chromatography (HRGC), using external standards as the method of determination and thin layer chromatographic (TLC). The results show that both plants have a similar chromatographic profile. However, M. robusta exhibited abo...

The evaluation of weight average molecular weight (Mw) and molecular weight distribution represents one of the most controversial aspects concerning the characterization of low molecular weight heparins (LMWHs). As the most commonly used method for the measurement of such parameters is high performance size exclusion chromatography (HP-SEC), the soundness of results mainly depends on the approp...

A simple, sensitive and accurate reversed phase high performance liquid chromatographic method for terbinafine and bezafibrate drugs. This method is developed for terbinafine and bezafibrate drugs. Reversed phase chromatographic separation of the two drugs was performed a C18 column is used with different mobile phases of methanol, water, ammonium dihydrogen phosphate and methanol, acetonitrile...

The amino-acid taurine has been shown to be a normal urinary constituent (Dent, 1948). Employing a quantitative chromatographic technique a diminished taurine excretion in cystinuria (Stein, 1951) and in Wilson's disease (Stein, Bearn, and Moore. 1954) has been detected. An increased taurine excretion. on the other hand, has been used as a sensitive index of minor liver damage in infectious hep...

In this study, a rapid, precise, accurate, specific and sensitive ion-paired reverse phase liquid chromatographic method has been developed for the simultaneous estimation of nebivolol hydrochloride and valsartan in their capsule formulation. The chromatographic method was standardized using a HIQ sil C(18) column (250x4.6 mm i.d., 5 mum particle size) with UV detection at 289 nm and flow rate ...

A Simple fast and precise reversed phase high performance liquid chromatographic method is developed for the Deflazacort drug. Chromatographic separation was performed a C18 column (250×4.6 mm) as a stationary phase with the mobile phase of Acetonitrile, methanol and water (90:5:5 v/v). Flow rate is 1.0 ml/min the detection of wave length is 230 nm. This method was validated for linearity, accu...