Collision tumors are that have at least two types of in the same anatomical site with no area mixing within transition zone. In 2010 WHO classification neuroendocrine consists an adenocarcinoma component and a carcinoma which each components accounts for 30% tumor. Such defined as mixed adenoneuroendocrine carcinomas. Occurrence exocrine endocrine pancreas is extremely rare. The aim our study w...

Chromogranin A is produced in many endocrine cell types, and is widely used as a marker in endocrine-cell pathology and secretory-cell biology. There is some evidence that it may be proteolytically processed to yield the putative pancreatic regulatory peptide, pancreastatin, and, in order to characterize the relevant pathways in gastrointestinal and pancreatic endocrine cells, we have used, in ...

AIMS Immunostaining of chromogranin identifies gastrointestinal mucosal endocrine cells. The detailed distribution and significance of chromogranin positive cells in colorectal carcinomas and in transitional mucosa remain unclear. The aim of this study was to clarify these aspects. METHODS The distribution of chromogranin positive cells was studied by immunohistochemical methods in normal epi...

Developing cotton (Gossypium hirsutum) fibers, cultured in vitro with their associated ovules, were used to compare the effects of two herbicides that inhibit cellulose synthesis: 2,6-dichlorobenzonitrile (DCB) and an experimental thiatriazinebased herbicide, CGA 3259615. CGA 3259615 in nanomolar concentrations or DCB in micromolar concentrations causes inhibition of synthesis of crystalline ce...

BACKGROUND Chemotherapy is the principal treatment method for patients with advanced non-small-cell lung cancer (NSCLC). Treatment with platinum-based and novel chemotherapeutic regimens, compared to monotherapy, slightly increases the response rates to 20-40%. The predictive and prognostic values of molecular factors are highly variable; however, data on clinical-demographic factors are still ...

The ECL cell is the most common cell type in the oxyntic mucosa of the stomach. It is producing a number of peptides and amines where histamine and chromogranin A seems to be the most important and abundant products. Recent data indicate a direct correlation between ECL-cell mass and circulating chromogranin A levels. Chromogranin A and its splice products might serve as growth promoting agents...