the short arm of rye (secale cereale l.) chromosome 1 (1rs), besides being part of the rye genome, is present in many hundred wheat cultivars as either 1rs.1bl or 1rs.1dl wheat-rye translocation. in this study, the distribution of the wheat–rye translocation was examined in 33 iranian winter and spring wheat cultivars, nine of which had a known donor of 1rs.1bl translocation and the other 24 we...

Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder included in the broader diagnostic category of myeloproliferative neoplasms, associated with fusion by BCR gene at chromosome 22q11 to ABL1 gene at chromosome 9q34 with the formation of the Philadelphia (Ph) chromosome. In 2-10% of CML cases, the fusion gene arises in connection with a variant translocation, involving chromoso...

Chromosomal translocation is one mechanism by which cellular oncogenes may be activated during tumorigenesis. The translocation of the abl oncogene to the Philadelphia chromosome in chronic myelogenous leukemia (CML) results in a new RNA transcript that fuses sequence from chromosome 22 to sequence from the abl oncogene. This RNA presumably codes for a new abl-related protein product found in C...

the short arm of rye 1r chromosome (1rs) carries genes for resistance to diseases and pests. the presence of the 1rs arm also enhance adaptation, stress tolerance and yield potential of bread wheat. in the present study 17 bread wheat cultivars were screened to identify 1bl.1rs translocation (t1bl.1rs) by isoelectric focusing, c-banding and fluorescence in situ hybridization (fish) methods. iso...

A 3 1/2-year-old female with clinical features of Down's syndrome was found to have extra chromosome material on the long arm of one of the X chromosomes, 46,XXq+. The parental karyotypes were normal. In the light of the clinical features of the proband an the banding characteristics of the extra chromosome material, the patient was thought to have a de novo (X;21) translocation. The results of...

The frequency of the Robertonian (ROB) translocation in newborn babies is approximately one in 1000. Robertsonian translocation is an unusual type of chromosome rearrangement caused by two particular chromosomes joining together. The aim of the study was to analyze the segregation of the ROB translocations in 13 male carriers, and to verify a possible inter-chromosomal effect (ICE) of the ROB t...

Objective: Infertility is defined as absence of a healthy baby or pregnancy despite one-year regular unprotected sexual intercourse. While primary infertility called the at all, secondary inability couples who have had least one child to become pregnant. Chromosome anomalies are an important cause both male and female infertility. In this study, we aimed discuss results chromosome analysis with...

OBJECTIVE To determine the diagnostic features of Robertsonian (Rob) translocation (11; 13) in mice and the mechanisms underlying the effect on spermatogenesis and reproductive decline. METHODS A Rob translocation (11; 13) mouse model was established by cross-breeding, and confirmed by chromosome analysis. Chromosome aberrations and translocation patterns were identified in mice with Rob tran...

Analysis of a group of human/rodent somatic cell hybrids with nucleic acid probes prepared from cloned human variable region (VH), junctional (JH), and constant region (C epsilon) heavy chain immunoglobulin genes indicates that all of these IgH genes are localized on the subtelomeric (q32) band of chromosome 14. Somatic cell hybrids were isolated in selective medium after fusing human fibroblas...