The C. elegans gene ced-12 functions in the engulfment of apoptotic cells and in cell migration, acting in a signaling pathway with ced-2 Crkll, ced-5 DOCK180, and ced-10 Rac GTPase and acting upstream of ced-10 Rac. ced-12 encodes a protein with a pleckstrin homology (PH) domain and an SH3 binding motif, both of which are important for ced-12 function. CED-12 acts in engulfing cells for cell c...

We present spectrophotometric imaging mid–IR observations of the reflection nebula Ced 201. Ced 201 is a part of a molecular cloud illuminated by a B9.5V star moving through it at more than 12 km s−1. The spectra of Ced 201 give evidence for transformation of very small carbonaceous grains into the carriers of the Aromatic Infrared Bands (AIBs), due to the radiation field of the illuminating st...

Allocation methodological choices in Life Cycle Assessment (LCA) is a relevant issue for the Circular Bioeconomy context. The recent Product Environmental Footprint Guide from European Commission includes Formula (CFF) as new way to deal with energy recovery/recycling processes. This paper investigated CFF vs. other different LCA allocation methods Brazilian briquette production. A cradle-to-ga...

Enforcing security often requires the two legitimate parties of a communication to determine whether they share a secret, without disclosing information (e.g. the shared secret itself, or just the existence of such a secret) to third parties—or even to the other party, if it is not the legitimate party but an adversary pretending to impersonate the legitimate one. In this paper, we propose CED ...

Recent progress in nanotechnology and electrochemical methods can be applied to fine control of the size, crystal structure, and surface properties of iron oxide nanoparticles. Here we appliedcathodic electrochemical deposition (CED) as an efficient and effective tactic for synthesisand double coating of surface of superparamagnetic iron oxide nanoparticles (SPIONs). In first step, bare Fe3O4 n...

Programmed cell death in Caenorhabditis elegans is initiated by the binding of EGL-1 to CED-9, which disrupts the CED-4/CED-9 complex and allows CED-4 to activate the cell-killing caspase CED-3. Here we demonstrate that the C-terminal half of EGL-1 is necessary and sufficient for binding to CED-9 and for killing cells. Structure of the EGL-1/CED-9 complex revealed that EGL-1 adopts an extended ...

BACKGROUND Three principal genes are involved in developmental programmed cell death (PCD) in the nematode worm Caenorhabditis elegans. The ced-3 and ced-4 genes are both required for each PCD, whereas ced-9 acts to prevent the death-promoting actions of these genes in cells that are destined to survive. Vertebrate homologues of both ced-3 and ced-9 have been identified as the genes encoding th...

We cloned the C. elegans gene ced-1, which is required for the engulfment of cells undergoing programmed cell death. ced-1 encodes a transmembrane protein similar to human SREC (Scavenger Receptor from Endothelial Cells). We showed that ced-1 is expressed in and functions in engulfing cells. The CED-1 protein localizes to cell membranes and clusters around neighboring cell corpses. CED-1 failed...

Malnutrition, often accompanied by low serum levels of micronutrients, was common in HIV-infection prior to the introduction of highly active antiretroviral therapy (HAART), and is still common in much of the world that has limited access to antiretroviral therapy (ART). Chronic diarrhea, anorexia, malabsorption, impaired nutrient storage, increased energy demands and altered metabolism were th...