results findings showed that the genotype -607a/a is associated with the susceptibility to chronic hepatitis b. furthermore, allele c at position -137 is suggested to play a protective role against development of chronic hbv infection. conclusions host genetic factors play an important role in determining the outcome of hbv infection. it is suggested that il-18 genotype -607 a/a is associated w...

conclusions the use of sof + pr regimen or ldv/sof can significantly reduce the incidence of complications associated with the disease. for example, short and long-term outcomes are better than the current drug regimens for hcv genotype 1 patients in all stages of the disease. objectives this study is aimed to assess the cost-effectiveness of the three drug regimens of pegylated interferon and ...

conclusions according to the results, total direct medical costs for hcv patients in iran exceeded 12 billion ppp$ in (inf-rbv) treatment and 55 billion ppp$ in (peg-rbv). results average direct medical costs for the courses treated with conventional interferon plus ribavirin (inf-rbv) were 4,403 ppp$, and 20,010 ppp$ for peg-interferon plus ribavirin (peg-rbv) courses. there was an increase of...

background pegylated interferon alfa plus ribavirin protocol is currently considered the most efficient hepatitis c treatment. however, no evidence of costs comparison among common viral genotypes has been published. objectives we aimed to assess core drivers of hepatitis c medical care costs and compare cost effectiveness of this treatment among patients infected by hepatitis c virus with geno...

background rapid virological response (rvr) strongly predicts sustained virological response (svr) in patients with chronic hepatitis c (chc), and abbreviates antiviral therapy in some patients. objectives to identify factors predicting virological relapse (vr) in chc patients who attained rvr. patients and methods medical records of 133 chc patients with an rvr after completing 24 weeks of ant...

context viral hepatitis and the consumption of alcohol are recognized as important reasons for the development of liver disease throughout the world. it would also seem that chronic alcoholism causes more severe and rapid progression of liver disease in patients with chronic hepatitis c, leading to more frequent liver cirrhosis and hepatocellular carcinoma. evidence acquisition the data for thi...

chronic hepatitis c might lead to several immunological dysfunctions. studies have shown a positive association between hepatitis c virus (hcv) infection and psoriasis. these results suggest that the infection may be one of the triggering factors for the development or exacerbation of psoriasis. here, we present a case of chronic hcv infection with psoriasis who developed exacerbation of skin l...

conclusions some il-10 promoter gene polymorphisms predisposed the infected hepatitis b virus cases to cirrhosis in our study population. patients and methods totally, 166 patients with chronic hepatitis b infection were enrolled. genotypes at different positions (i.e. -819, - 592, and - 1082) in the il-10 gene promoter were determined. results the c/a genotype at position -592, c/t genotype at...

background il-33 is a novel member of the il-1 family, which has been shown to play an important role in t helper 2 (th2)-associated immune responses. recent studies have suggested a possible role for il-33 in the pathogenesis of liver damage during acute and chronic hepatitis; furthermore, il-33 may be involved in the development and progression of liver fibrosis. objectives to evaluate serum ...

Background & Aims: Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease worldwide. The clearance of the HCV is dependent on cytokines control led by genetic. The purpose of this study was to investigate the impact of Lymphotoxin (LT-A) polymorphism at +252 in susceptibility to chronic hepatitis C. Methods: In this case-control study, 120 individuals infected by HCV and ...