OBJECTIVES/HYPOTHESIS The genetic factors leading to a predisposition to otitis media are not well understood. The objective of the current study was to develop a tag-single nucleotide polymorphism (SNP) panel to determine if there is an association between candidate gene polymorphisms and the development of chronic otitis media with effusion. STUDY DESIGN A 1:1 case/control design of 100 cas...

Inflammation of the middle ear, known clinically as chronic otitis media, presents in different forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative otitis media (CSOM). These are highly prevalent diseases, especially in childhood, and lead to significant morbidity worldwide. However, much remains unclear about this disease, including its aetiology, initiat...

Following a study reporting a fourfold increase in the occurrence of chronic otitis media in patients with ankylosing spondylitis, this prospective study examines this association with respect to severity, duration of disease, and acute phase in ankylosing spondylitis. Forty two consecutive patients with classical ankylosing spondylitis seen at the rheumatology clinic of a teaching hospital whe...

OBJECTIVE Despite evidence that therapeutic mastoidectomy does not improve outcomes in noncholesteatomatous chronic otitis media, it remains widely performed. An up-to-date systematic review is undertaken and conclusions drawn regarding the best evidence-based practice of its management. DATA SOURCES PubMed, Google Scholar, Medline Embase, Cochrane, and Web of Science. REVIEW METHOD A combi...

Objectives. The aim of this study was to analyze the epidemiological and clinical aspects of chronic otitis media and its therapeutic processes in our context. Patients and Methods. In a prospective study over a period of 1 year (March 2009-February 2010), 79 patients with chronic otitis media have been cared for in the otolaryngology ward of the University Hospital of Ouagadougou. Results. Chr...

Background: Otitis is the most common infectious disease of the ear with internal and external cranial complications. If the infection is in the middle ear, it causes otitis media. If the infection is in the external ear, it’s along with otitis externa (OE). Different types of otitis media include acute otitis media (AOM), chronic otitis media (COM) and Otitis media with effusion (OME). This st...

Portier, F., T. Van Den Abbeele, E. Lecain, E. Sauvaget, B. Escoubet, P. Tran Ba Huy, and P. Herman. Oxygen modulates Na1 absorption in middle ear epithelium. Am. J. Physiol. 276 (Cell Physiol. 45): C312–C317, 1999.— The physiology of the middle ear is primarily concerned with keeping the cavities air filled and fluid free to allow transmission of the sound vibrations from the eardrum to the in...

Chronic suppurative otitis media, infection of the middle ear, is a common disease in the developing countries and the complications associated with it still pose a major problem in the developing countries. The proximity of the middle ear cleft and mastoid air cells to the extracranial and intracranial compartments places structures located in these areas at increased risk of infectious compli...