Chrysin is a 5,7-dihydroxyflavone and was recently shown to potently inhibit enterovirus 71 (EV71) by suppressing viral 3C protease (3C(pro)) activity. In the current study, we investigated whether chrysin also shows antiviral activity against coxsackievirus B3 (CVB3), which belongs to the same genus (Enterovirus) as EV71, and assessed its ability to prevent the resulting acute pancreatitis and...

This study aims to elucidate the effects of chrysin on human ER-negative breast cancer cell line, MDA-MB-231. The study demonstrated that treatment of MDA-MB-231 cells with 20 microM chysin for 48 h significantly inhibited the growth of MDA-MB-231 cells and induced cytoplasmic lipid accumulation in the cells, but that the observed of cell death was not caused by apoptosis. The expression of PPA...

The known flavone, chrysin (1) and the known flavone glycoside, chrysin-7-O-(β-D-glucopyranoside) (2) together with vomifoliol, loliode and cinnamic acid have been isolated for the first time from the leaves and flowers of Calycotome spinosa (L.). Lamk, theirs structures were established on the basis of spectroscopic technical; H-, C-NMR, 2D NMR and MS (I.E).

The UDP-glucuronosyltransferases (UGTs) have long been known to be inducible by various chemicals, including drugs, although the extent of induction in general has been modest. In the present study, we determined the ability of the dietary flavonoid chrysin to induce UGT activity, protein and mRNA. When pretreating human hepatoma Hep G2 cells with 25 microM chrysin, the glucuronidation of chrys...

Chrysin is a bioactive flavonoid found in pollens, passion flowers, honey, royal jelly, and propolis, which commonly used as an ingredient natural food supplements primarily responsible for their pharmacological properties. A transparent chrysin-loaded microemulsion (CS-ME) prepared through ternary phase diagram was evaluated use antihyperalgesic formulation. It formulated with 40% Labrasol® (s...

Oxidative stress is known as the leading factor responsible for varicocele-related infertility and for that reason, many antioxidant therapies have been proposed. Considering that, we evaluated the reproductive outcomes and fertility of varicocelized rats and the impact of chrysin within these parameters. The animals were allocated into three groups: sham (control), varicocele treated via gavag...

Flavonoids is an intensively studied group of natural compounds with antioxidant, antineoplastic, antihyperglycemic, cardioprotective, and neuroprotective properties. The present study intends to investigate the geroprotective action of three selected flavonoids (naringin, luteolin, chrysin) in two model organisms, Caenorhabditis elegans and Drosophila melanogaster. Luteolin and chrysin were sh...

Chrysin is a flavonoid with various biological activities. However, its low water solubility and strong metabolism render oral bioavailability rather poor. This study aimed to develop stable solid dispersion formulation of chrysin improve the dissolution chrysin, so as increase antihyperlipidemic A was prepared using solvent evaporation method, Plasdone® S630 hydrophilic carrier. The formulatio...