Hyperinsulinaemic insulin resistance is characteristic of many, if not all, women with polycystic ovary syndrome (PCOS). We will review evidence suggesting that hyperinsulinaemia promotes hyperandrogenism in PCOS by two distinct and independent mechanisms: (i) by increasing circulating ovarian androgens; and (ii) by directly reducing serum sex hormone-binding globulin concentrations. The net re...

body weight is influenced by both food intake and energy expenditure. acylated ghrelin enhances appetite, and its circulating level is suppressed by growth hormone. data on the acylated ghrelin responses to exercise of different intensities in obese individuals are currently not available. this study examined the effects of an intermittent exercise protocol on acylated ghrelin levels and hunger...

We aimed to assess the parathyroid hormone (PTH) concentration in pregnant women at beginning of pregnancy (1st trimester) and within days before delivery (3rd evaluate its determinants. From September 2014 through December 2015 a cross-sectional study, 204 1st trimester 203 3rd were recruited. Blood samples collected measure PTH circulating 25-hydroxy-vitamin D (25(OH)D) concentrations. Lifest...

INTRODUCTION Prolonged critically ill patients reveal low circulating thyroid hormone levels without a rise in thyroid stimulating hormone (TSH). This condition is labeled "low 3,5,3'-tri-iodothyronine (T3) syndrome" or "nonthyroidal illness syndrome (NTI)" or "euthyroid sick syndrome". Despite the low circulating and peripheral tissue thyroid hormone levels, thyrotropin releasing hormone (TRH)...

Background & aimsTo investigate the acute effects of intravenous vs enteral meal administration on circulating bile acid and gut hormone responses.MethodsIn a randomized crossover design, we compared duodenal (via nasoduodenal tube) parenteral (intravenous) over 180 min identical mixed meals concentrations in eight healthy lean men. We analysed responses two periods: intraprandial period from t...

Antisera to triiodothyronine were shown to contain large quantities of the hormone, well in excess of normal circulating concentrations. Extracting the triiodothyronine from the antiserum with alkaline ethanol yielded an antibody of increased affinity. Use of this antibody in a radioimmunoassay resulted in a fourfold increase in sensitivity as compared with the unextracted material.

Behaviorally subordinate female common marmoset monkeys (Callithrix jacchus) exhibit pronounced, chronic reductions of circulating cortisol levels. Cortisol suppression in these animals is mediated in part by adrenocortical hyporesponsiveness to adrenocorticotropic hormone (ACTH). In addition, we hypothesized that social subordination may activate a central, neurally mediated mechanism to furth...

OBJECTIVE — Accumulating research suggests low-circulating vitamin D concentrations, i.e., 25-hydroxyvitamin-D [25(OH)D], may be associated with an increased prevalence of metabolic syndrome; however, previous studies have not accounted for parathyroid hormone (PTH) levels. We examined the association of 25(OH)D and PTH with the prevalence of metabolic syndrome in a community-based cohort of ol...

The modulatory effects of gestational age and circulating concentrations of progesterone, 5-pregnane-3,20-dione, and estradiol-17 on the uterine sex steroid hormone receptor levels of the African elephant were investigated. Uterine tissue biopsies and blood samples were obtained from animals culled in the Kruger National Park. Estrogen and progesterone receptor concentrations were determined in...