Objective(s): Stem cell therapy is believed to be as a promising treatment strategy for tissue repair and regeneration. The plasticity specification of the adult stem cells, such as MSCs, has enabled that these cells to be used in the treatment of a broad spectrum of diseases like liver disorders. In this study, the production of urea and Albumin (Alb), glycogen storage, and expression of some ...

PURPOSE To investigate the effects of epidermal growth factor receptor (EGFR), cytokeratin 19 (CK19), cytokeratin 20 (CK20) and survinin gene expression on local control (LC) and overall survival (OS) in patients with locally advanced head and neck cancer (LAHNC) who were administered radiotherapy (RT). MATERIALS AND METHODS Twenty-six patients who were admitted to Uludag University Medical F...

Recently, the rearrangement of RET proto-oncogene has been reported to be the most common genetic change in papillary thyroid carcinoma (PTC). However, its prevalence has been reported variably and its relation to clinical outcome has been controversial. The characteristic nuclear features of PTC usually render the diagnosis, but problem arises with equivocal cytologic features that are present...

BACKGROUND Malignant germ cell tumours are the most common malignant tumours in young men. They are histologically divided into seminomas and non-seminomas. Non-seminomas are further subdivided into embryonic carcinomas, yolk sac tumours, chorionic carcinomas, and teratomas. For the therapeutic management it is essential to differentiate between these histological subtypes. METHODS Investigat...

The incidence of Papillary Thyroid Carcinoma (PTC) has increased gradually in recent years, especially for Papillary Thyroid Microcarcinoma (PTMC). The purpose of this study was to evaluate the expression of Ki67, CK19, Galectin-3 and HBME-1 protein in PTMC and evaluate the clinical significance of differential diagnosis. The specimens of 80 PTMC cases and 40 benign papillary hyperplasia thyroi...

BACKGROUND & OBJECTIVES Cancer stem cells (CSCs) may be responsible for tumour recurrence and resistance to chemotherapy in hepatocellular carcinoma (HCC). This study was carried out to evaluate the association between histological parameters and liver CSCs (LCSC) in HCC, and to compare distribution of liver CSCs in HCC associated with and without hepatitis B virus (HBV) infection. METHODS Se...

BACKGROUND Immunocytochemistry and RT-PCR have been widely used for the detection of circulating tumor cells in patients with breast cancer but their specificity is limited. Our purpose is to utilize a convenient and specific technology to detect circulating tumor cells in breast cancer patients. METHODS To determine the sensitivity and specificity of our method, A431 cells were serially dilu...

BACKGROUND Alopecia is one of the most important hair follicle (HF) disorders, which is divided into scarring (cicatricial) and nonscarring (noncicatricial) types. OBJECTIVE The aim of this study is to investigate the expression of stem cell (SC) markers such as cytokeratin (CK) 17 and CK19 in scarring and nonscarring alopecia. MATERIALS AND METHODS Thirty patients with scalp alopecia (15 w...

BACKGROUND The overexpression of Ck19 antigen occurs frequently in human carcinomas. The strategy and mechanism of radioimmunotherapy using Re-188-mAbCx-99 to Ck19 on human cervical carcinoma cells was investigated in this study. MATERIALS AND METHODS Using mAbCx-99, the overexpression of Ck19 protein in lysates of cell lines and tissues from various patients' cervixes were verified by immuno...

Primary liver cancer may derive from hepatocytes or bile duct cells. Recently it has been suggested the progenitor cell compartment is also a target cell population for carcinogenesis (1). Hepatic progenitor cells (HPC) are located in the most peripheral branches of the biliary tree, i.e., the ductules and canals of Hering. Biliary epithelium is normally CK7 and CK19 positive. HPC are also immu...