Subsets of natural killer (NK) cells are characterized by the expression of inhibitory and/or stimulatory receptors specific for major histocompatibility complex (MHC) class I determinants. In mice, these include the Ly49 family of molecules. One mechanism by which tumor cells may evade NK cell killing is by expressing the appropriate MHC class I and binding inhibitory Ly49 receptors. Therefore...

The class D amplifier is not well known in audio applications. Its excellent power ratio (greater than 90%) is the most important advantage. The MOS transistors switching power stage is able to drive a useful power up to 100W to the loud speaker. However, designing such an amplifier is more difficult than designing a classical class A or AB power amplifier. The distortion level is also slightly...

A class-AB switched current memory cell is proposed. The circuit decomposes the input signal into two components by a low-voltage class-AB current splitter and subsequently processes the individual signals by two low switching error class-A memory cells. As a consequence, the output current obtained by recombination of the separated signals can be higher than the bias current and features low e...

For a broader view of the role of H-2M as an accessory molecule in antigen presentation, we investigated the degree to which different MHC class II isotypes and alleles depend on H-2M to function in vivo. We generated H-2M-deficient animals expressing Ek/b or Ak molecules in addition to the Ab molecules already present in the mutant strain, and compared the ability of the different MHC class II...

HLA antibodies (HLA ab) in transplant candidates have been associated with poor outcome. However, clinical relevance of noncytotoxic antibodies after heart transplant (HT) is controversial. By using a Luminex-based HLA screening, we retested pretransplant sera from HT recipients testing negative for cytotoxic HLA ab and for prospective crossmatch. Out of the 173 consecutive patients assayed (52...

BACKGROUND A number of distinct stress signaling pathways in myocardium cause cardiac hypertrophy and heart failure. Class II histone deacetylases (HDACs) antagonize several stress-induced pathways and hypertrophy. However, cardiac hypertrophy induced by transgenic overexpression of the homeodomain only protein, HOP, can be prevented by the nonspecific HDAC inhibitors trichostatin A and valproi...

1. Throughout the paper we shall denote by R a Riemann surface. For a domain Í2 in P, we represent by AB(Q) the class of all the singlevalued bounded analytic functions on the closure Ü. For a meromorphic function / on a domain ß, we use the notation viw\f, Q.) to express the number of times that/ attains w in ß. Definition 1. We say that REWIb if the maximum principle suplen \fip)\ =sup3,ean \...

Recently, researchers have investigated the causal nature of attentional bias for threat (AB) in the maintenance of anxiety disorders by experimentally manipulating it. They found that training anxious individuals to attend to non-threat stimuli reduces AB, which, in turn, reduces anxiety. This effect supports the hypothesis that AB can causally impact the maintenance of anxiety. At a fundament...

in this paper, we introduce a class of rings which is a generalization of reversible rings. let r be a ring with identity. a ring r is called central reversible if for any a,b ∈ r, ab=0 implies ba belongs to the center of r. since every reversible ring is central reversible, we study sufficient conditions for central reversible rings to be reversible. we prove that some results of reversible ri...