The SAGE Project is a multi-institution effort to enable encoding and dissemination of interoperable, computable clinical practice guidelines. We have developed a standards-based guideline-knowledge representation model that specifies computable guideline content. We incorporate a “virtual medical record” that mediates both the encoding of guideline knowledge and the subsequent mapping to idios...

Background Integrating guideline knowledge with clinical workflow plays a critical role in effective guideline implementation strategies. Eight information management services promote integration of computerized systems into clinical workflow—recommendation, documentation, explanation, presentation, registration, communication, calculation and aggregation. The Guideline Elements Model (GEM) use...

background: granulocyte colony stimulating factors (gcsf) are high cost agents commonly recommended for primary and secondary prophylaxis of chemotherapy-induced neutropenia and febrile neutropenia. gcsfs have been shown to be beneficial in some patient subgroups, although they are probably overused in clinical settings. the american society of clinical oncology (asco) guidelines summarize curr...

Pain is the most frequent and distressing symptom in cancer patients. As part of a worldwide effort to improve the quality of pain control, several clinical guidelines for the management of cancer pain have been published and revised in the last decade. The Japanese Society of Palliative Medicine first published a Japanese clinical guideline for the management of cancer pain in 2000. Since then...

The success of clinical decision-support systems requires that they are seamlessly integrated into clinical workflow. In the SAGE project, which aims to create the technological infra-structure for implementing computable clinical practice guide-lines in enterprise settings, we created a deployment-driven methodology for developing guideline knowledge bases. It involves (1) identification of us...