BACKGROUND Circulating cell-free DNA (ccf-DNA) is becoming an important biomarker for cancer diagnostics and therapy monitoring. The isolation of ccf-DNA from plasma as a "liquid biopsy" may begin to replace more invasive tissue biopsies for the detection and analysis of cancer-related mutations. Conventional methods for the isolation of ccf-DNA from plasma are costly, time-consuming, and compl...

The U.S. government recently implemented rules for awarding compensation to individuals with cancer who were exposed to ionizing radiation while working in the nuclear weapons complex. Under these rules, chronic lymphocytic leukemia (CLL) is considered to be a nonradiogenic form of cancer. In other words, workers who develop CLL automatically have their compensation claim rejected because the c...

Chronic lymphocytic leukemia (CLL) is a type of lymphoid neoplasms that occurs with the accumulation of clonal b-cell lymphocytes in organs such as bone marrow, blood and lymph nodes [1]. This leukemia is one of the most common leukemia in western countries which appear in adults, however; the prevalence of CLL in eastern countries is lower than western countries [2,3]. However, this malignancy...

CLL cell trafficking between blood and tissue compartments is an integral part of the disease process. Idelalisib, a phosphoinositide 3-kinase delta (PI3Kδ) inhibitor causes rapid lymph node shrinkage, along with an increase in lymphocytosis, prior to inducing objective responses in CLL patients. This characteristic activity presumably is due to CLL cell redistribution from tissues into the blo...

Objective: Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of CD5+CD19+ B cells in bone marrow and peripheral blood. Recent studies indicated that expression IL-10, AID mir-155 which are regulated STAT3 increased CLL patients. regulator (Breg) secrete IL-10 suppress immune system. While show similar immunophenotypic properties to Breg cells, they also thought be function...

Chronic lymphocytic leukemia (CLL) is a type of lymphoid neoplasms that occurs with the accumulation of clonal b-cell lymphocytes in organs such as bone marrow, blood and lymph nodes [1]. This leukemia is one of the most common leukemia in western countries which appear in adults, however; the prevalence of CLL in eastern countries is lower than western countries [2,3]. However, this malignancy...

it has recently been shown that ror1, a member of the receptor tyrosine kinase family, is overexpressed in leukemic b cells of chronic lymphocytic leukemia (cll) and a subset of acute lymphoblastic leukemia (all). in this comparative study the expression profile of ror1 mrna was investigated in iranian patients with cll and acute myelogenous leukemia (aml) and the results were compared with tho...

Chronic lymphocytic leukaemia (CLL) is characterized by the accumulation of CD5/CD19 B leukemic cells in blood and secondary lymphoid organs. Despite significant advances in its therapy, especially during the last two decades, the disease still remains incurable and new treatment options need to be developed. Currently, the CD20 antibody, rituximab, is used to treat CLL in combination with chem...

 Backgrounds: MicroRNAs (miRNAs) have crucial roles in cellular and molecular processes related to different malignancies including chronic lymphocytic leukemia (CLL). In recent years the most studies demonstrated that the expression of miR-95, alter in several diseases. Long non-coding RNAs (lncRNAs) a heterogeneous group of non-coding and regulatory RNAs. The present study investigated the as...

Medical diagnosis, notably concerning tumors, has been transformed by artificial intelligence as well deep neural network. White blood cell identification, in particular, necessitates effective diagnosis and therapy. Blood Cell Cancer (WBCC) comes a variety of forms. Acute Leukemia Lymphocytes (ALL), Myeloma (AML), Chronic (CLL), (CML) are white cancers for which detection is time-consuming pro...