BACKGROUND Bullous pemphigoid is the most common autoimmune blistering skin disease of the elderly. Because elderly people have low tolerance for standard regimens of oral corticosteroids, we studied whether highly potent topical corticosteroids could decrease mortality while controlling disease. METHODS A total of 341 patients with bullous pemphigoid were enrolled in a randomized, multicente...

The aim of this work was to assess in vivo the anti-inflammatory efficacy and tolerability of clobetasol propionate (CP) loaded lecithin/chitosan nanoparticles incorporated into chitosan gel for topical application (CP 0.005%). As a comparison, a commercial cream (CP 0.05% w/w), and a sodium deoxycholate gel (CP 0.05% w/w) were also evaluated. Lecithin/chitosan nanoparticles were prepared by se...

Due to the anti-inflammatory and vasodilator effects of topical corticosteroids, they help in treating atopic eczema, psoriasis, chronic hand localized vitiligo, among other dermatological diseases. Clobetasol propionate (CP) is most popular medication used treat plaque psoriasis. It has anti-inflammatory, antimitotic, antipruritic, immunosuppressive characteristics. The USFDA approved CP 0.025...

IMPORTANCE Alopecia areata is an idiopathic cause of hair loss with limited therapeutic repertoire. OBJECTIVE To compare the efficacy and safety of a high- vs low-potency topical corticosteroid in pediatric patients. DESIGN, SETTING, AND PARTICIPANTS This single-center, randomized, blind, 2-arm, parallel-group, superiority trial was carried out over a 24-week period at a tertiary referral a...

of lichen planus follicularis tumidus and Hashimoto’s thyroiditis. An Bras Dermatol. 2017;92(4):585-7. Mailing address: Hatice Kaya Ozden Kocaeli Derince Training and Research Hospital Dermatology Department 41900 Kocaeli / Turkey E-mail: [email protected] We observed a slightly itchy, tumid, violaceous plaque in our patient only in the left retroauricular region and classic lichen planus lesion...

Dapsone has been used successfully as adjuvant therapy for bullous pemphigoid (BP). The effectiveness of dapsone for this indication, however, remains controversial. We evaluated the effectiveness and adverse events of dapsone (1.0-1.5 mg/kg per day) in combination with oral methylprednisolone (tapering doses of 0.5 mg/kg per day) and topical clobetasol propionate (initially applied once daily ...

The hybrid system based on nanoparticles (NPs) self-assembled by the conjugations of hyaluronic acid with cholesterol (HA-Chol NPs) combined with nicotinamide (NIC) for tacrolimus (FK506), ie, FK506 NPs-NIC, has been confirmed to exhibit a significant synergistic effect on FK506 permeation through and into intact skin; thus, it may be a promising approach for FK506 to effectively treat skin dis...