Recurrent miscarriage is the leading problem among pregnant women’s of present scenario. Though there are many causes for this such as anatomical, hormonal, genetic, clotting factors, environment and infections. But till date no research has been done to consider weak pelvic floor muscles one cause recurrent miscarriage. In study we have explained about effect on Along with discussed diagnostic...

We present a silica nanoparticle (SNP) functionalized with polyphosphate (polyP) that accelerates the natural clotting process of the body. SNPs initiate the contact pathway of the blood-clotting system; short-chain polyP accelerates the common pathway by the rapid formation of thrombin, which enhances the overall blood-clotting system, both by accelerating fibrin generation and by facilitating...

Polylysine has been shown to possess various biological activities. It is bacteriostatic (Katchalski, Bichowski-Slomnitzki & Volcani, 1953) and virostatic (Stahmann, Graf, Patterson, Walker & Watson, 1951); it inhibits thromboplastic activity (de Vries et al. 1951), fibrinolysis (Ginsburg, de Vries & Katchalski, 1952), the proteolytic activity of pepsin (Katchalski, Berger & Neumann, 1954) and ...

The aim of this study was to examine the effect of estrogen on fibrinogen clotting time in rabbit model experimentally. The study was performed on 14 white New Zealand race female prepubertary rabbits at two months old weighing meanly 1.4±0.3 kg. Blood samples was taken from ear veins of the rabbits and first fibrinogen clotting time levels were measured to obtain control values. Next day, fema...

We have developed a radioimmunoassay for human thrombin using rabbit anti-human thrombin IgG. The assay can measure 2 ng thrombin/ml plasma, 500-fold more sensitive than clotting assays. Human prothrombin is less reactive in the assay than thrombin by at least four orders of magnitude, and there is no demonstrable cross-reactivity with human factor Xa, the clotting factor structurally most simi...

This paper describes microfluidic experiments with human blood plasma and numerical simulations to determine the role of fluid flow in the regulation of propagation of blood clotting. We demonstrate that propagation of clotting can be regulated by different mechanisms depending on the volume-to-surface ratio of a channel. In small channels, propagation of clotting can be prevented by surface-bo...

The process of human blood clotting involves a complex interaction of continuous-time/continuous-state processes and discrete-event/discrete-state phenomena, where the former comprise the various chemical rate equations (which can be written as differential equations) and the latter comprise both threshold-limited behaviors and qualitative facets of the coagulation cascade. We model this proces...

Thromb Haemost 2007; 98: 20–23 To browse through old work is a pleasure in the indian summer of a career, not devoid of nostalgia.As the large majority of our early work appeared inThrombosis and Diathesis Haemorrhagica, the present issue is an appropriate occasion to do so and to review old results, holding them against the light of our present day knowledge – and apologising beforehand for th...