Oligodendrocytes (OLs) extend arborized processes that are supported by microtubules (MTs) and microfilaments. Little is known about proteins that modulate and interact with the cytoskeleton during myelination. Several lines of evidence suggest a role for 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNP) in mediating process formation in OLs. In this study, we report that tubulin is a major CN...

Changes in brain white matter are prominent features of the aging brain and include glial cell activation, disruption of myelin membranes with resultant reorganization of the molecular components of the node of Ranvier, and loss of myelinated fibers associated with inflammation and oxidative stress. In previous studies, overexpression of CNP, a key myelin protein, was implicated in age-related ...

OBJECTIVE Calcific aortic valve disease is associated with the differentiation of valvular interstitial cells (VICs) to myofibroblast and osteoblast-like cells, particularly in the fibrosa layer of the valve. Previous studies suggested that C-type natriuretic peptide (CNP) protects against calcific aortic valve disease to maintain homeostasis. We aimed to determine whether CNP inhibits VIC path...

The present study determined circulating concentrations of atrial natriuretic peptide (ANP) and C-type natriuretic peptide (CNP) in Wistar-Kyoto (WKY) rats and spontaneously hypertensive rats (SHR) and also investigated the vasorelaxing action of ANP and CNP on isolated contracted aorta. We also defined the vasorelaxing action of a novel and newly synthesized 27-amino acid chimera of ANP and CN...

OBJECTIVE The aim of this study was to investigate the effect of various C-type natriuretic peptide (CNP) sequences (genomic DNA [CNPDNA], cDNA derived from mRNA [CNPcDNA], and sequence coding for 22 amino acids of the mature CNP [CNP22aa]) on the growth of primary porcine vascular cells. METHODS AND RESULTS Gene transfer was performed with cationic lipid DOCSPER or linear polyethylenimine. A...

A spectral model of luminescence the two-component exciton-activated semiconductor quantum dot (QD) layered plasmon composite nanoparticle (CNP) with a dielectric core and conductive shell in an external magnetic field is constructed, taking into account inhomogeneity quasi-stationary electric generated by QD CNP region, outside framework approximation dipole polarizability CNP. The tensor form...

Lee, Sook Jeong, Sung Zoo Kim, Xun Cui, Suhn Hee Kim, Kyung Sun Lee, Yu Jeong Chung, and Kyung Woo Cho. C-type natriuretic peptide inhibits ANP secretion and atrial dynamics in perfused atria: NPR-B-cGMP signaling. Am. J. Physiol. Heart Circ. Physiol. 278: H208–H221, 2000.— The purpose of the present experiments was to define the role of C-type natriuretic peptide (CNP) in the regulation of atr...

C-type natriuretic peptide (CNP), initially isolated from porcine brain [3], is the most recently characterized member of the natriuretic peptide family. The human CNP gene consists of at least two exons and an intron [4]. Whereas synthesis of atrial and brain natriuretic peptides (ANP and BNP) has been demonstrated mainly in the heart, but also in various other organs [2, 5], CNP m R N A in ma...

Simulation results for optical metamaterials (MTMs) derived from active coated nano-particle (CNP) inclusions for operation in the visible range of the spectrum between 400nm and 700nm are presented. Several examples of optical MTMs designed with these inclusions are characterized, including two-dimensional (2D) CNP metafilms; three-dimensional (3D) periodic CNP arrays; and 3D random CNP distri...

C-type natriuretic peptide (CNP) possesses nitric oxide-like signaling mechanisms and actions in the vasculature, including the inhibition of fibrosis and vascular remodeling through counterregulation of transforming growth factor-β (TGF-β) signaling. The leucine zipper protein transforming growth factor stimulated clone 22 domain 1 (TSC22D1), cloned via its presumed binding to a GC-rich elemen...