Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect multiple different organs, including the kidneys and central nervous system (CNS). Conventional radiological examinations in SLE patients include volumetric/ anatomical computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound (US). The utility of these modalities is limited, however, due to the complexi...

BACKGROUND AND PURPOSE Multiple sclerosis and neuropsychiatric systemic lupus erythematosus are autoimmune diseases with similar CNS inflammatory and neurodegenerative characteristics. Our aim was to investigate white matter tract changes and their association with cognitive function in patients with MS and those with neuropsychiatric systemic lupus erythematosus compared with healthy controls ...

Several studies have suggested a pathogenetic role of paraproteinaemias in PNS damage. Over the few last years, the presence of symptomatic or subclinical PNS lesions in CNS diseases like multiple sclerosis has been described. On the other hand, CNS demyelinating lesions and cervical atrophy have been reported in patients affected by chronic inflammatory demyelinating polyradiculoneuropathy (CI...

Introduction Patients with systemic lupus erythematous (SLE) often develop neuropsychiatric disease. Central nervous system (CNS) manifestations of SLE occur in about half of all patients, and psychiatric presentations are seen with a prevalence of 35% to 60% in this group. Electroconvulsive therapy (ECT) also known as electroshock therapy is a psychiatric treatment in which electricity/electri...

An antibody was detected in the sera from patients with systemic lupus erythematosus (SLE) and central nervous system (CNS) involvement that reacted with a 50-kD antigen in the plasma membrane of brain synaptic terminals. The 50-kD antigen was solubilized with Triton X-100 from preparations enriched with synaptic plasma membranes, and was partially purified by molecular sieve filtration column ...

Introduction Psychiatric manifestations in juvenile systemic lupus erythematosus (JSLE) are not uncommon, and they often pose diagnostic and therapeutic challenges. Magnetic resonance imaging (MRI) of the brain is often without abnormalities. Fluorodeoxyglucose positron emission tomography (FDG PET) detects relative reductions in regional cerebral glucose metabolism, and has been suggested as a...

Systemic Lupus Erythematosus (SLE) is a chronic autoimmune diseasein which tissue-binding auto-antibodies and immune complex depositioncause damage to multiple organs systems.We report rare case of SLE in 31-year-old male patient. He has past history unprovoked deep vein thrombosis right lower limb for 8 years, treated with anticoagulant therapy but not evaluated further. The patient went on de...