Presenting features and natural history were assessed in 48 children with acute lymphoblastic leukaemia less than 2 years of age at diagnosis. Of these, 16 were less than 1 year (group 1) and 32 were between 1 and 2 years (group 2). Results were compared with a group of 348 children between the ages of 2 and 14 years (group 3) diagnosed over the same period. The children in group 1 presented wi...

r t o c t r h a w n b p n unanticipated consequence of recent successes in the treatment of non–central nervous system (CNS) malignancies has been a steady ncrease in the frequency of brain and spinal fluid elapse. This pattern has been well-documented in paients with breast cancer, small cell and non-small cell ung cancer, and non-Hodgkin lymphoma (NHL) and ay well emerge in other common (colo...

BACKGROUND Breast cancer central nervous system (CNS) metastases are an increasingly important problem because of high CNS relapse rates in patients treated with trastuzumab and/or taxanes. PATIENTS AND METHODS We evaluated data from 2887 node-positive breast cancer patients randomised in the BIG 02-98 trial comparing anthracycline-based adjuvant chemotherapy (control arms) to anthracycline-d...

Background: Methotrexate has an important role in treatment of acute leukemia. We measured methotrexate level in CSF and blood of children with acute lymphoblastic leukemia to determine complications and outcomes. Materials and Methods: One hundred and twenty patients (73 male, 47 female), with mean age at diagnosis of 6.1 years (11mo_15years) entered the study. Patients were divided into two...

BACKGROUND Primary adrenal lymphoma (PAL) is an extremely rare subtype of extranodal non-Hodgkin's lymphoma. Some researchers have reported some of the characteristics of PAL and its association with poor prognosis; however, the clinicopathological features of PAL remain to be elucidated. METHODS From 2008 to 2011 we experienced seven cases of PAL in our institutions. We retrospectively analy...

The treatment of leukemia remains the success story of cancer. The patients with acute lymphoblastic leukemia survive longer and longer, with the rates of long time remission of over 80% in children and 30-40% in adults. Therefore, increased attention is given to diagnose and prevent central nervous system (CNS) complications, not only in order to increase the survival, but also in order to pre...

Background Compared to intrathecal methotrexate (IT MTX), triple intrathecal therapy (TIT) has shown promising results in decr...

Extramedullary relapse (EMR) of acute promyelocytic leukemia (APL) is a rare entity, with predilection to involve the central nervous system (CNS). Risk factors include leukocytosis of > 10 × 109/L, bcr3 isoform, microgranular variant, age > 45 years and development of subarachnoid hemorrhage (SAH) during induction therapy. We report a case of APL who completed induction and consolidation thera...

In the last decades, our knowledge on the management of diffuse large B-cell lymphomas (DLBCL) has expanded remarkably. Nevertheless, some important questions, like the impact of dose dense chemotherapy, the role of consolidation radiotherapy, the selection of the best candidates for new target drugs, the optimal management for patients with high International Prognostic Index (IPI) scores and ...