BACKGROUND At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred. METHODS Immunogenicity and safety were assessed in 871 healthy subjects aged 19-40 years who were randomised into six groups to receive co-administration or sequential administration of TIV ...

The effects of co-administration of a cassava rich diet and alcohol in rats were investigated. The animals were divided into four groups (1) Control, (2) Alcohol, (3) Cassava and (4) Alcohol + Cassava. Consumption of alcohol along with cassava reduced the alcohol induced toxicity which was evidenced by the lower activities of GOT, GPT, GGT, acid phosphatase and alkaline phosphatase in the liver...

conclusions: the co-administration of saffron aqueous extract and safranal reduced toxic effects of safranal in acute and sub-acute toxicities. background: saffron and its constituents are widely used around the world as a spice and medicinal plant. different constituents in medicinal herbs are thought to have the potential to induce useful and/or adverse effects. so, efforts have been made to ...

This study compared the efficacy and safety of co-administered ezetimibe + simvastatin with atorvastatin monotherapy in adults with hypercholesterolemia. Seven hundred eighty-eight patients were randomized 1:1:1 to 3 treatment groups; each group was force-titrated over four 6-week treatment periods: (1) 10 mg of atorvastatin as the initial dose was titrated to 20, 40, and 80 mg; (2) co-administ...

objective: atrazine (atz) as a widely used herbicide is considered as a potent endocrine disrupter which adversely affects reproductive systems in both genders. this study aimed to assess the effects of testosterone (t)- and vitamin e (vite)- alone and their co-administration on testicular function and sperm parameters after exposure to atz in rats. materials and methods: in this experimental s...

Methylphenidate, which inhibit dopamine transporter is effective in the treatment of ADHD (attention deficit hyperactivity disorder), but long term use of this drug is often associated with addiction and dependence. Locomotor sensitization development to psychostimulants like methylphenidate is an important contributor to drug abuse induced by psychostimulants. Different studies have shown that...

introduction: hospital has a complex and special structure and the important question that hospital management facing with is how technology can change structure. in the near future, no factor like it is able to change the structure of organization. this research is a way to know the effect of it on triple dimensions of organization structure includes complexity, formalization, and centralizati...

introduction : tardive dyskinesia is one of the major side effects of long-term neuroleptic treatment. increased reactive oxygen species and oxidative stress has been proposed as possible etiopathologic mechanisms. ginkgo biloba extract (egb) is a natural antioxidant. we investigated the effects of ginkgo biloba extract on neuroleptic-induced orofacial dyskinesia in rats, a potential animal mod...

intranasal vaccination is particularly a striking route for mucosal immunization, due to the ease of administration and the induction of both mucosal and humoral immunity. however, soluble antigens (ag) are not sufficiently taken up after the nasal administration and need to be co-administered with adjuvants, penetration enhancers or encapsulated in particles. so, in this study, tetanus toxoid ...