Cobalt is a well-established inducer of hypoxia-like responses, which can cause gene modulation at the hypoxia inducible factor pathway to induce erythropoietin transcription. Cobalt salts are orally active, inexpensive, and easily accessible. It is an attractive blood doping agent for enhancing aerobic performance. Indeed, recent intelligence and investigations have confirmed cobalt was being ...

Silica ferric hydrogensulfate is an efficient heterogeneous catalyst for the cyclization of 2- aminochalcones to the corresponding 2,3-dihydroquinolin- 4(1H)-ones. This intramolecular aza Michael reaction was carried out in high yields using chalcones bearing of electron donating and electron withdrawing groups. The catalyst is reusable without significant decreases in its activity after four t...

This listing of the class of cobalt and cobalt compounds that release cobalt ions in vivo (as defined below) supersedes the previous listing of cobalt sulfate in the Report on Carcinogens. The compound cobalt sulfate was first listed in the Eleventh Report on Carcinogens in 2004 as reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity in experimental an...

Extraction of alcohols from n-tetradecane using various extraction solvents has been investigated at a range temperatures 295 to 393 K under ambient pressure. On the basis experimental liquid–liquid equilibrium data, distribution ratio and selectivity were calculated for 1-octanol, 1-decanol, 1-dodecanol (C8–C12) in 1-ethyl-3-methylimidazolium hydrogensulfate [C2mim][HSO4] sulfolane. Results sh...

In this study, 18 copies of PLAVIX tablets containing clopidogrel hydrogensulfate were compared to the innovator drug product for uniformity of mass, impurity profile, content, dissolution properties and stability. In order to be able to separate the R-enantiomer of clopidogrel, an enantiospecific liquid chromatographic method was used to determine the impurities and to perform the assay. The p...

Hydration directly affects the mobility, thermodynamic properties, lifetime and nucleation rates of atmospheric ions. In the present study, the role of ammonia on the formation of hydrogen bonded complexes of the common atmospheric hydrogensulfate (HSO(4) (-)) ion with water has been investigated using the Density Functional Theory (DFT). Our findings rule out the stabilizing effect of ammonia ...

A study of polyaniline (PANI) doping with various cobalt compounds, that is, cobalt(II) chloride, cobalt(II) acetate, and cobalt(II) salen, is presented. The catalysts were prepared by depositing cobalt compounds onto the polymer surface. PANI powders containing cobalt ions were obtained by one- or two-step method suspending PANI in the following acetonitrile/acetic acid solution or acetonitril...

BACKGROUND Occupational exposure to cobalt is well established in hard metal manufacture. Cobalt is known to cause contact allergy, asthma, hard metal lung disease, and lung cancer. The relationship between skin exposure and uptake determined in blood has not been extensively investigated. OBJECTIVE To examine whether skin and inhalable air exposure to cobalt contributes to uptake, determined...

To determine the effects of cobalt chloride on human submandibular gland cells, HSG cells were exposed to various concentrations of cobalt chloride. Cobalt chloride induced cytotoxicity and cell death in HSG cells as determined by phase-contrast microscopy and WST-1 cell viability assay. By using the Hoechst 33342 staining, marked nuclear condensation and fragmentation of chromatin were observe...