This study was conducted to investigate long-term neurocognitive outcomes and to determine associated risk factors in a cohort of Korean survivors of childhood acute lymphoblastic leukemia (ALL). Forty-two survivors of ALL were compared with 42 healthy controls on measures of a neurocognitive test battery. We analysed potential risk factors (cranial irradiation, sex, age at diagnosis, elapsed t...

Background: Brain tumors in the cerebellum site, especially in the cranial nuclei, are most commonly associated with cognitive impairment in children, but the differences in dimensions of cognitive impairments in pediatric benign and malignant tumors are rarely studied. Meanwhile, cognitive impairments in this area are required to be widely studied. This study aimed at using Computerized Addenb...

Neurocognitive deficits are serious sequelae that follow cranial irradiation used to treat patients with medulloblastoma and other brain neoplasms. Cranial irradiation causes apoptosis in the subgranular zone of the hippocampus leading to cognitive deficits. Valproic acid (VPA) treatment protected hippocampal neurons from radiation-induced damage in both cell culture and animal models. Radiopro...

objective: ocular morbidity is widely observed when radiotherapy includes the orbit. oxidative stress generated by irradiation is responsible for this complication. in different studies, it has been shown that melatonin has antioxidative properties and a radioprotective role. the aim of this study was to evaluate the antioxidant role of melatonin against radiation-induced oxidative injury in ra...

The case of a middle aged man who developed a meningioma directly underneath the site of a naevus treated with radiotherapy as a child, is presented. Epidemiological evidence and reports of similar cases suggesting meningiomas may be a sequel to irradiation, are reviewed.

Parkinsonism and rapid cognitive impairment may have many causes, but only a few specific treatment. Cranial dural arteriovenous fistula (DAVF) represents 10-15% of intracranial malformations. Clinical manifestations depend on location venous drainage. It is common the presence pulsatile tinnitus, bruits headache or papilledema. Progressive decline an unusual presentation due to bilateral thala...

BACKGROUND Hypercoagulability is observed in vascular dementia, including Binswanger disease. However, the correlation between hypercoagulability, leukoaraiosis, and dementia remains unclear. OBJECTIVE To examine how activation of the coagulation fibrinolysis correlates with leukoaraiosis and dementia. PATIENTS AND METHODS Thrombin-antithrombin complex (TAT), prothrombin fragment(1 + 2) (F1...

BACKGROUND Prophylactic cranial irradiation reduces the incidence of brain metastasis in patients with small-cell lung cancer. Whether this treatment, when given to patients in complete remission, improves survival is not known. We performed a meta-analysis to determine whether prophylactic cranial irradiation prolongs survival. METHODS We analyzed individual data on 987 patients with small-c...