Behavioural semantics for specifications plays a crucial role in the formalization of the developments process, where a specification need not to be implemented exactly but only so that the required system behaviour is achieved. There are two main approaches to the definition of behavioural semantics: the internal one (called behavioural semantics) and external one (called abstractor semantics)...

We report a case of colchicine-induced myopathy, in which the initial presenting and predominant clinical feature was respiratory muscle dysfunction; there was also chronic renal failure and electromyographically-measured myopathy. Discontinuation of colchicine led to marked improvement. Colchicine discontinuation was the only therapy performed (other medications were unchanged), and within 3 w...

‘Perspectives on Open and Distance Learning: Open Educational Resources: An Asian Perspective’ offers a look at the current utilization of open educational resources (OER) in higher education (HE) in Asia. This compilation of country perspectives and cases studies is co-published by the Commonwealth of Learning (COL) in Vancouver, Canada and OER Asia operated out of the Institute for Research a...

OBJECTIVE Intrauterine administration of polidocanol foam (PF) can create fallopian tube occlusion in nonhuman primates. The objective of this study was to determine if PF-induced tubal obstructions contain collagen in the extracellular matrix. STUDY DESIGN We compared tissue samples of the intramural fallopian tube obtained from previous studies evaluating the effects of intrauterine infusio...

background and objectives: study of deleterious effect of neurotoxins on the animals' brain is a fascinating research plan. in this project, the damage effect of colchicine on the hippocampal cornu ammonis 1 (ca1) was examined by the studying the hippocampal tissue. materials and methods: injections of colchicine (1-75 μg/rat, intra- hippocampal ca1) were performed in cannulated male wistar rat...

BACKGROUND It is controversial whether myocardial fibrosis in end-stage dilated cardiomyopathy (DCM) is associated with altered collagen type I/type III (Col I/Col III) ratio. METHODS AND RESULTS Patients with DCM (ejection fraction [EF] <50%, n=12) and with mild global left ventricular dysfunction (EF >50%, n=18) were examined. Col I, Col III, and transforming growth factors-beta1 (TGF-beta1...

Abstract Tissue repair engineering supported by nanoparticles and stem cells is an efficient strategy for promoting the healing potential of damaged tissues. In this study, we prepared various nanomaterials including pure Pul, Col, Pul–Col, Pul–Au, Pul–Col–Au, Col–Au to investigate their physicochemical properties, biocompatibility, biological functions, differentiation capacities, anti-inflamm...

PURPOSE Colchicine is commonly used in the management of gout; however, older persons have higher risks of toxicity. Accordingly, the Screening Tool of Older Person's potentially inappropriate Prescriptions (STOPP) criteria for colchicine consider >3 months of treatment as potentially inappropriate in older persons. Recent evidence also suggests lower dosing of colchicine is as effective and re...

Familial Mediterranean fever (FMF) is the most frequent autoinflammatory disease which can be well controlled with lifelong use of colchicine. Daily colchicine use has been shown to reduce the frequency, severity, and duration of attacks. Colchicine also has been found to be effective in decreasing the prevalence of amyloidosis. Therapeutic oral dose of colchicine (0.5-2.0 mg/ day) may cause cr...

The effect of eugenol on colchicine transport across an isolated rat intestinal membrane was studied using an in vitro diffusion chamber system. We found that eugenol increased the absorptive transport of the drug efficiently. The effect of eugenol on intestinal absorption of colchicine in an oral administrative nanoemulsion formulation was also demonstrated in vivo. The colchicine nanoemulsion...