Introduction Timely identification of rare diseases is often challenging. In Germany, approximately 4 million people are affected by conditions [1]. Systems based on artificial intelligence (AI), such as symptom checker applications, can help to detect diseases.

Aim of the case report was to present a rare case of CAD with Malaria. Methods and materials were as per the clinical protocol and investigations done in the department of pathology.Cold Agglutinin Disease (CAD) is a subgroup of autoimmune Haemolytic Anemia (AIHA). Cold reactive immune globulins (agglutinins) which are directed against erythrocyte surface antigen (‘1’ antigen) are essential for...

Cold agglutinin disease is an uncommon disease with potential to cause hemolysis and thrombosis during hypothermic cardiac surgery. Antiphospholipid syndrome is also rare disease with hypercoagulation tendacy. Perioperative management of both these diseases is challenging. We present successful perioperative management of high risk Bentall surgery in patient with both these dreadful diseases.

provided the original work is properly cited. CC Cold agglutinin, an autoantibody that combines with the red blood cell (RBC) carbohydrate antigen, is known to trigger hemolysis with agglutination at temperatures of 0-4C [1]. Cold agglutinin combined with RBC in a peripheral body exposed to a cold environment returns to the center of the body and combines with the complement; these processes fo...

The red cells of patients with chronic hemolytic anemia due to cold agglutinins are agglutinated by antiglobulin serum in a nongamma reaction due to the coating of beta-globulins, C'4 and C'3. The red cells of such patients are abnormally resistant to C' hemolysis by cold agglutinin. Normal red cells can be made equally resistant to C' hemolysis by incubation with cold agglutinin and normal ser...