نتایج جستجو برای: combined chemoradiation
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BACKGROUND Limited-disease small-cell lung cancer (LD-SCLC) can be cured with combinations of systemic chemotherapy and local treatments, predominantly radiation therapy. While systemic control inside the brain has been further improved with the inclusion of prophylactic cranial irradiation, long-term local control remains suboptimal, even with newer chemoradiation protocols. METHODS The auth...
The salvage operation for esophageal cancer is one of the most interesting topics today among Japanese doctors treating this form of malignant tumor. This topic has been selected as the focus of symposia and panel discussions at many annual meetings of surgical-, esophageal-, or digestive-disease–related societies in Japan. In parallel, definitive chemoradiation therapy has recently shown progr...
BACKGROUND Stage IIIA non-small-cell lung cancer (NSCLC) is highly heterogeneous due to differences in the size of the primary tumor and the extent and location of nodal disease. Although the addition of surgery to chemoradiation did not improve overall survival (OS) for stage IIIA patients in a randomized intergroup trial (INT 0139), subset analyses of the trial suggest that a trimodality appr...
PURPOSE Gemcitabine is a promising adjuvant treatment for patients with resected pancreatic adenocarcinoma and its use in combination with radiotherapy is under exploration. Human equilibrative nucleoside transporter 1 (hENT1) and human concentrative nucleoside transporter (hCNT) 1 and 3 are the major transporters responsible for 2',2'-difluoro-2-deoxycytidine (gemcitabine) uptake into cells. T...
BACKGROUND The CARTS study is a multicenter feasibility study, investigating the role of rectum saving surgery for distal rectal cancer. METHODS/DESIGN Patients with a clinical T1-3 N0 M0 rectal adenocarcinoma below 10 cm from the anal verge will receive neoadjuvant chemoradiation therapy (25 fractions of 2 Gy with concurrent capecitabine). Transanal Endoscopic Microsurgery (TEM) will be perf...
Chemoradiation is the current standard of care in patients with locally advanced carcinoma cervix. Although extensive literature is available on the acute morbidity due to chemoradiotherapy in women with cancer cervix, most of the studies have been done at carefully prepared academic centers in developed countries (Rose et al., 1999; Maduro et al., 2003; Ikushima et al., 2006; Mahantshetty et a...
OBJECTIVE The objective of this article was to evaluate therapeutic outcomes of elderly patients with glioblastoma multiforme (GBM) treated by surgery followed by combined modality therapy and compare achievable outcomes to those of a younger age population. METHODS AND MATERIALS Seventy-eight adult patients with histologically confirmed grade IV astrocytoma were treated at King Hussein Cance...
Management of cancer of the oropharynx has undergone a paradigm shift in recent years following the realisation that HPV infection is both an aetiologic and prognostic factor for a subset of oropharyngeal squamous cell carcinoma; the introduction of transoral robotic surgery (TORS) to resect oropharyngeal tumours; as well as attempts to reduce the morbidity of chemoradiation by accepting smalle...
AIMS AND BACKGROUND In recent years, preoperative chemoradiation has received growing interest for the treatment of locally advanced pancreatic cancer. In an attempt to improve resectability and disease control, we used preoperative radiation therapy and concomitant 5-fluorouracil in a combined modality therapy protocol. The aim of the study was to evaluate definitive results in terms of toxici...
Gastric cancer remains one of the most common malignancies worldwide. Despite the significant advances in surgical treatment and multimodality strategies, prognosis has modestly improved over the last two decades. Locoregional relapse remains one of the main issues and the combined chemoradiation treatment seems to be one of the preferred approaches. However, more than ten years after the hallm...
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