Recent legislation has emphasized comparative effectiveness, including both the American Recovery and Reinvestment Act of 2009 and the Patient Protection and Affordable Care Act of 2010, which established the Patient Centered Outcomes Research Institute (PCORI) to foster comparative effectiveness research (CER).1,2 Defined as “the generation and synthesis of evidence that compares the benefits ...

background: for treatment of severe alcohol withdrawal syndrome, high dose benzodiazepines (bzds) may cause delirium and over-sedation. phenobarbital (pbt) is a long-acting barbiturate effective for the treatment of alcohol withdrawal. given the potential benefits of pbt, we sought to investigate the effectiveness of pbt as adjunctive treatment for alcohol withdrawal. methods: this was a retros...

organophosphate (op) compounds are frequently used agorchemicals for deliberate self-harm in some parts of the world resulting in high mortality and morbidity. pralidoxime (2pam) is the most widely used and trialed oxime for treatment of op poisoning. there have been variations over the results of trials using 2pam for op poisoning. 2pam therapy has led to favorable outcomes in some studies, wh...

BACKGROUND The transfer of new scientific discoveries into healthcare interventions requires that basic and clinical researchers work together with health care providers to generate team science. These innovative models require translational teams, and need to extend beyond the academic environment. The future of translational science requires partnerships with the healthcare community as well ...

PURPOSE Because of an increasing demand for quality comparative effectiveness research (CER), methods guidance documents have been published, such as those from the Agency for Healthcare Research and Quality (AHRQ) and the Patient-Centered Outcomes Research Institute (PCORI). Our objective was to identify CER methods guidance documents and compare them to produce a summary of important recommen...

0

The Nature of Comparative Research in Philosophy of Education: Faaraabee's Method M.H. Mirzaamohammadi, Ph.D. Comparative research, from a philosophical perspective in education, goes beyond the mere comparison of two ideas or subjects, and necessitates both judgment and critical analysis. Considering the complexities of the educational processes, doing comparative research in educati...