Iron oxide nanoparticles (IONPs) are promising nanomaterials for biomedical applications. However, their inflammatory potential has not been fully established. Here, we used a lepirudin anti-coagulated human whole blood model to evaluate the potential of 10 nm IONPs to activate the complement system and induce cytokine production. Reactive oxygen species and cell death were also assessed. The I...

The immune haemolytic anaemias comprise a set of diseases characterized by shortened red blood cell survival (haemolysis) mediated by the action of antibodies and serum complement. The haemolysis is evidenced by a raised reticulocyte count in the absence of blood loss. Activity of the immune system is diagnosed by the presence of antibody or fragments of complement components (mainly C3 and C4)...

this study was conducted to determine the effects of administration of different concentration of aloe vera crud extract (ace) as a food supplement on growth performance, immune response and disease resistance against aeromonas hydrophila (chester) infection in cyprinus carpio. 360 juvenile c.carpio were randomly divided into four equal groups in triplicates. groups 1 to 4 were fed by basal foo...

the present study was conducted to investigate the clinical effects and possible side effects of yarrow extract ( achillea millefolium l.) as feed additive on biochemical blood parameters and growth performance of rainbow trout ( oncorhynchus mykiss ). fishes were treated with 0 (control), 0.1, 0.5 and 1% of yarrow extract for 30 days. plasma alanine aminotransferase (alt), aspartate aminotrans...

BACKGROUND Scabies is a contagious skin disease caused by the parasitic mite Sarcoptes scabiei. The disease is highly prevalent worldwide and known to predispose to secondary bacterial infections, in particular by Streptococcus pyogenes and Staphylococcus aureus. Reports of scabies patients co-infected with methicillin resistant S. aureus (MRSA) pose a major concern for serious down-stream comp...

BACKGROUND Exposure of blood to artificial surfaces, as in cardiopulmonary bypass, induces an inflammatory response involving complement, leukocyte and platelet activation. To elucidate the specific role of complement in this process, studies were performed on blood circulated in polyvinyl chloride tubing in the absence and presence of complement inhibitors. Parallel experiments were performed ...

The serum of a 23-yr-old woman with prolonged disseminated gonococcal infection syndrome failed to normally promote hemolysis of sensitized sheep red blood cells (RBC). The patient's serum was deficient in the eight component of complement (C8) as determined by functional assays, immunoelectrophoresis, and quantitative immunoprecipitation. Functional titers of each of her other complement compo...

Paroxysmal nocturnal hemoglobinuria is a rare disorder of hemopoietic stem cells. Affected individuals have a triad of clinical associations - intravascular hemolysis, an increased risk of thromboembolism, and bone marrow failure. Most of the symptoms experienced in this disease occur due to the absence of complement regulatory proteins on the surface of the red blood cells. Complement activati...

ABO histo-blood group antigens have been postulated to modify pathogen spread through the action of natural antibodies and complement. The antigens are generated by a polymorphic glycosyltransferase encoded by 2 dominant active and a recessive inactive allele. In this study we investigated whether ABO sugars are incorporated into the envelope of HIV-1 virions. HIV vectors derived from cells exp...