objectives : the purpose of this in vitro study was to compare the marginal adaptation and fracture resistance of a zirconia-based all-ceramic restoration with two preparation designs. materials and methods: twenty-four mandibular premolars were randomly divided into two groups (n=12); the conventional group received a peripheral shoulder preparation and the modified group received a buccal sho...

Epigenetic dysfunction has been widely implicated in several diseases especially cancers thus highlights the therapeutic potential for chemical interventions in this field. With rapid development of computational methodologies and high-performance computational resources, computer-aided drug design has emerged as a promising strategy to speed up epigenetic drug discovery. Herein, we make a brie...

We consider lead discovery as active search in a space of labelled graphs. In particular, we extend our recent data-driven adaptive Markov chain approach, and evaluate it on a focused drug design problem, where we search for an antagonist of an αv integrin, the target protein that belongs to a group of Arg-Gly-Asp integrin receptors. This group of integrin receptors is thought to play a key rol...

The guided local search method has been successfully applied to a significant number of NP-hard optimization problems, producing results of similar caliber, if not better, compared to those obtained from algorithms specially designed for each singular optimization problem. Ranging from the familiar TSP and QAP to general function optimization problems, GLS sits atop many well-known algorithms s...

Accurate assessment of the potential binding mode of drugs is crucial to computer-aided drug design paradigms. It has been reported that evodiamine acts as an agonist of the vanilloid receptor Transient receptor potential vanilloid-1 (TRPV1). However, the precise interaction between evodiamine and TRPV1 was still not fully understood. In this perspective, the homology models of TRPV1 were gener...

The new drug discovery is found to be a time consuming and costly process. Recently, a trend towards the use of in-silico computational chemistry and molecular modeling for computer aided drug design has gained significant momentum. This review is an investigation of the applications of different software in drug design. The modern drug discovery process is steadily becoming more information dr...

Modern drug discovery is characterized by the production of vast quantities of compounds and the need to examine these huge libraries in short periods of time. The need to store, manage and analyze these rapidly increasing resources has given rise to the field known as computer-aided drug design (CADD). CADD represents computational methods and resources that are used to facilitate the design a...

The drug and pharmaceutical industry is a multi-billion dollar business that spends billions of dollars every year trying to optimize drugs and the way they are delivered to the body. Researchers and drug companies alike are mostly concerned with both the quantity and duration of drug presence in the body. Formulating new technologies and delivery mechanisms is a very cumbersome process that ca...

objectives : marginal adaptation is important for long-term success of full-coverage restorations. the aim of this study was to determine the effect of porcelain firing cycle and different thicknesses of ips e.max core on marginal accuracy of all-ceramic restorations. materials and methods : a standard stainless steel die with 0.8 mm classic chamfer finish line and 10° taper was used in this in...

during dental education, dental students learn how to examine patients, make diagnosis, plan treatment and perform dental procedures perfectly and efficiently. however, progresses in computer-based technologies including virtual reality (vr) simulators, augmented reality (ar) and computer aided design/computer aided manufacturing (cad/cam) systems have resulted in new modalities for instruction...