s | 5 Conclusions: Aripiprazole demonstrated its efficacy in maintaining abstinence from metamphetamine use in Thai patients with metamphetamine dependence following metamphetamine psychosis. It was found to be safe and well tolerated. Keyword: methamphetamine, aripiprazole, dependence, abstinence PM294 Association between polymorphism of COMT gene and domestic violence in Han and Uygur on alco...

BACKGROUND Interindividual variability in the processing of reward might be partially explained by genetic differences in the dopamine system. Here, we study whether brain responses (event-related potentials [ERPs], oscillatory activity) to monetary gains and losses in normal human subjects are modulated as a function of two dopaminergic polymorphisms (catechol-O-methyltransferase [COMT] valine...

OBJECTIVE The catechol O-methyltransferase (COMT) gene affects how long dopamine acts in the prefrontal cortex. The Methionine polymorphism, which results in a slower breakdown of prefrontal dopamine, is associated with better adult prefrontal cortex function. The authors investigated the relation between the COMT gene polymorphism and cognitive performance in children. METHOD Children were t...

s | 5 Conclusions: Aripiprazole demonstrated its efficacy in maintaining abstinence from metamphetamine use in Thai patients with metamphetamine dependence following metamphetamine psychosis. It was found to be safe and well tolerated. Keyword: methamphetamine, aripiprazole, dependence, abstinence PM294 Association between polymorphism of COMT gene and domestic violence in Han and Uygur on alco...

Following the biopsychosocial model of medicine, pathophysiological basis irritable bowel syndrome (IBS) is a combination biological, psychoemotional, and psychosocial factors, contribution each them to development this disorder remains unclear. Psychoemotinal which are involved in pathogenesis IBS, caused not only by environment but also metabolism catecholamines, particularly functional activ...

AIM Estrogens regulate several biological processes involved in the pathogenesis of myocardial infarction. Catechol-O-methyltransferase (COMT) is a key enzyme in the degradation of estrogens. There is a functional polymorphism in the COMT gene (Val158Met), affecting the activity of the enzyme. We investigated if the low activity genotype of COMT is associated with an altered risk of myocardial ...

Previous studies suggest that a single nucleotide polymorphism in the catechol-O-methyltransferase (COMT) gene (val158met) may modulate reward-guided decision making in healthy individuals. The polymorphism affects dopamine catabolism and thus modulates prefrontal dopamine levels, which may lead to variation in individual responses to risk and reward. We previously showed, using tasks that inde...

BACKGROUND The role of circulating levels of total homocysteine tHcy in the development of coronary heart disease (CHD) is still under debate. One reason for conflicting results between previous studies on homocysteine and heart diseases could be consequence of different interactions between homocysteine and genes in different study populations. Many genetic factors play a role in folate-homocy...

Velo-cardio-facial syndrome (VCFS) is caused by a micro-deletion of over 40 genes at the q11.2 locus of chromosome 22 and is a risk factor for the development of schizophrenia and other psychiatric disorders. COMT, one of the genes located in the deleted region, has been considered as a major candidate gene for genetic susceptibility in psychiatric diseases. Its functional polymorphism Val108/1...

It has been recently shown that Catechol O-methyltransferase (COMT) Val(158)Met polymorphism strongly influences prepulse inhibition (PPI) of the acoustic startle response (ASR) in healthy human volunteers. Given that schizophrenia patients exhibit impairment in PPI and that COMT is a putative susceptibility gene for schizophrenia, we investigated the impact of the COMT Val(158)Met polymorphism...