blood transfusion centers are under considerable pressure to produce platelet concentrates with a shelf life limit of 3 to 5 days. many approaches have been investigated experimentally to produce new hemostatically active platelet products that are capable of long term storage. in this article infusible platelet membrane will be explained as a platelet substitute versus conventional liquid-stor...

Until recently, cryoprecipitate has been the treatment of choice in patients with severe von Willebrand disease (vWD) because it can transiently correct low plasma levels of factor VIII coagulant activity (FVIII:C) and shorten or normalize the prolonged bleeding time (BT), the two laboratory hallmarks of the disease. However, cryoprecipitate may still transmit blood-borne viruses, whereas the d...

The concentrations of various trace elements and radionuclides have been measured in marine protein concentrates prepared from surface feeding fishes. As with concentrates prepared from benthic fishes, the 210Pb-210Po pair are the most significant radionuclides present. Concentrations of stable Pb, Co and Ag in certain concentrates are sufficiently high to contribute substantially to estimated ...

There are no large-scale data available describing the increments obtained with platelet concentrates stored for varying durations. Platelet concentrates prepared by standard techniques were stored at 22 degrees C with horizontal agitation in PL-732 bags and administered to clinically stable, nonalloimmunized recipients known to respond well to random donor platelet transfusions. The platelet c...

The mode of furfural accumulation was determined in aseptically filled containers of single-strength orange juice and concentrates during storage at six different temperatures. Results showed that furfural accumulated in orange juice more rapidly than in concentrates of 34,44, and 58 OBrix. There was 4 times the amount of furfural in orange juice (12 "Brix) than in concentrate (58 "Brix) stored...

Repeated exposure to foreign human leukocyte antigens (HLA) present on both platelets and leukocytes often results in refractoriness to transfusions of platelet concentrates. Evidence now exists which suggests that the leukocytes are more immunogenic and that their removal from blood products may delay or prevent the development of refractoriness. In this study, the ability of three blood filte...

Recombinant factor VIII and factor IX concentrates, human-plasma–derived albumin, and samples from previously untreated patients with hemophilia were examined for the presence of TT virus (TTV) by using polymerase chain reaction testing. Blood samples from the patients were obtained prospectively before and every 3 to 6 months after therapy was begun. TTV was detected in 23.5% of the recombinan...

The main feature of this new approach to platelet freezing is a controlled rate of addition and postthaw removal of 5#{176}/odimethylsulfoxide (DMSO). When DMSO was removed from fresh nonfrozen platelet concentrates before transfusion, no adverse effect on posttransfusion survival was observed. The 51Cr recovery of autologous fresh platelet concentrates in vivo was 65#{176}/o ± 5#{176}/o, while...

Recombinant factor VIII and factor IX concentrates, human-plasma-derived albumin, and samples from previously untreated patients with hemophilia were examined for the presence of TT virus (TTV) by using polymerase chain reaction testing. Blood samples from the patients were obtained prospectively before and every 3 to 6 months after therapy was begun. TTV was detected in 23.5% of the recombinan...