In 1961, Kerr, Harrison, Sherlock, and Walker described a series of children, all but one under 10 years ofage, whose main features were hepatosplenomegaly or bleeding oesophageal varices. They reviewed the published material fully, and differentiated their cases from 'juvenile cirrhosis' following neonatal hepatitis, blood group incompatibility, Wilson's disease, and fibrocystic disease of the...