The (micro-)finite element analysis based on three-dimensional computed tomography (CT) data of human bone takes place on complicated domains composed of often hundreds of millions of voxel elements. The finite element analysis is used to determine stresses and strains at the trabecular level of bone. It is even used to predict fracture of osteoporotic bone. However, the computed stresses can d...

background and objective: escherichia coli o157:h7, an emerging pathogen, causes severe enteritis and the extraintestinal complication of hemolytic-uremic syndrome. the goal of this study was to evaluate the conjugate of e. coli o157: h7 lipopolysaccharide (lps) with diphtheria toxoid (dt) as a candidate vaccine in mice model. material and methods: lps from e. coli o157:h7 was extracted by hot ...

Coupling recent imaging capabilities with microstructural finite element (μFE) analysis offers a powerful tool to determine bone stiffness and strength. It shows high potential to improve individual fracture risk prediction, a tool much needed in the diagnosis and treatment of osteoporosis that is, according to the WHO, second only to cardiovascular disease as a leading health care problem. We ...

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...

In this paper, we propose a new experimental method to investigate the fatigue crack growth mechanisms of submicron-scale cracks by using freestanding single edge notched micro-beams that are fabricated on the surfaces of conventional bending specimens with the focused ion beam technique. Three dimensional FEM simulations in conjugate with LEFM fracture analysis were carried out to correlate th...

The high computational cost involved in modeling of the progressive fracture simulations using large discrete lattice networks stems from the requirement to solve a new large set of linear equations every time a new lattice bond is broken. To address this problem, we propose an algorithm that combines the multiple-rank sparse Cholesky downdating algorithm with the rank-p inverse updating algori...

Basic relation between numerical range and Davis-Wielandt shell of an operator $A$ acting on a Hilbert space with orthonormal basis $xi={e_{i}|i in I}$ and its conjugate $bar{A}$ which is introduced in this paper are obtained. The results are used to study the relation between point spectrum, approximate spectrum and residual spectrum of $A$ and $bar{A}$. A necessary and sufficient condition fo...

elisa data is usually handled in the ms excel worksheets through different methods and different formulas. accurate and precise calculations of the data is time consuming and tedious. elisa analyzer was developed with a user friendly interface to streamline titration and analysis of the data obtained from elisa and improve rapid and lucid presentation of the results. the software can also help ...

The efficacy of methotrexate (MTX) as an antimetabolite chemotherapeutic agent highly depends on its blood circulation half-life. In our previous study, different conjugates of MTX (MTX-PEG) were synthesized, their physicochemical properties were investigated and MTX-PEG5000 was finally selected as optimum drug-conjugate for further investigations. In the current work, first the stability of MT...

Crustal scale fault zones extend below the brittle-ductile transition as ductile shear zones. Here we address question of which regime, brittle or ductile, initiates and controls overall system localization. Observations crustal but low displacement conjugate strike-slip faults show that they are typically nearly orthogonal, expected from plastic criteria. Sub-crustal faults, however, have acut...