OBJECTIVE To extend the information base on the hepatobiliary manifestations of neonatal lupus erythematosus (NLE) with regard to frequency of occurrence, clinical characteristics, and outcome. METHODS Review of records from the Research Registry for Neonatal Lupus. RESULTS Nineteen (9%) of 219 patients who had NLE and were enrolled in a national registry had probable or possible NLE hepato...

AIMS AND OBJECTIVE To study the clinical, biochemical and histopathological changes in the liver of patients of Plasmodium falciparum malaria with jaundice. MATERIAL AND METHOD This study was conducted on 50 PBF confirmed cases of Plasmodium falciparum malaria with jaundice. Detailed history, clinical examination, biochemical parameters for liver function test and blood for hepatitis B and C ...

REFERENCES 1. Hannam S, McDonnell M, Rennie JM. Investigation of prolonged neonatal jaundice. Acta Paediatr 2000;89:694–7. 2. National Institute for Health and Clinical Excellence. Neonatal Jaundice. Clinical Guideline 98, 2010. http://www.nice.org.uk/CG98 (accessed 1 September 2010). 3. Unal S, Koc E, Aktas A, et al. Prolonged jaundice in newborns: what is it actually due to? Gazi Med J 2003;1...

BACKGROUND: Widespread administration of COVID-19 vaccinations have led to reports rare but potentially serious side effects. METHODS: We present two cases acute hepatitis following mRNA BNT162b2 (Comirnaty, Pfizer-BioNTech) vaccination. RESULTS: A 25-year-old male presented hospital with progressive jaundice 5 days his second dose Comirnaty. Initial bloodwork revealed severe hepatocellular enzy...

Eisai hyperbilirubinemic mutant rats (EHBRs) with conjugated hyperbilirubinemia were recently derived from Sprague-Dawley rats (SDRs). The pharmacokinetic characteristics of the beta-lactam antibiotic cefpiramide (CPM), which is mainly excreted into bile, were investigated in 10- and 20-week-old EHBRs and were compared with those in 20-week-old healthy SDRs. The pharmacokinetic parameters of CP...

Isolated hyperbilirubinemia as a manifestation of alcoholic liver disease without significant liver abnormalities is seen very rarely. We report such a case where a patient with chronic alcoholism presented to the ER with acute jaundice with bilirubin of 24.8 mg/dl, predominantly conjugated in nature along with mild elevation of AST (76 IU/L). There were no other abnormalities of the liver func...