1539 Bilateral abdominal lipohypertrophy after continuous subcutaneous infusion of insulin Continuous subcutaneous infusion of insulin has brought about smooth control of blood glucose concentrations in many patients with brittle diabetes, and few local complications after long-term treatment have been reported. We describe a patient who developed appreciable bilateral abdominal lipohypertrophy...

OBJECTIVE Develop an efficient non-clinical method for identifying promising computer-based protocols for clinical study. An in silico comparison can provide information that informs the decision to proceed to a clinical trial. The authors compared two existing computer-based insulin infusion protocols: eProtocol-insulin from Utah, USA, and Glucosafe from Denmark. MATERIALS AND METHODS The au...

I n t e r v e n t i o n Patients were assigned to intensive (n = 765) or conventional (n = 783) insulin therapy. Intensive therapy was insulin infusion that was begun if the blood glucose level was > 6.1 mmol/L and adjusted to maintain normoglycemia (maximum insulin dose 50 IU/h). Conventional therapy was continuous insulin infusion by a pump that was begun if the blood glucose level was > 11.9...

BACKGROUND We retrospectively studied associations between bolus infusion of hydrocortisone and variability of the blood glucose level and changes in insulin rates in intensive care unit (ICU) patients. METHODS 'Glycemic variability' and 'insulin infusion rate variability' were calculated from and expressed as the standard deviation (SD) of all blood glucose levels and insulin infusion rates ...

The response of growth hormone, cortisol, and catecholamines to hypoglycaemia produced by a continuous intravenous infusion of insulin was investigated in 10 normal subjects and 15 patients with pituitary disease. The insulin infusion rate was started at 2 U/hour for adolescents, 4 U/hour for adults, and 6 U/hour for patients with acromegaly. If required the rate was increased during the test d...

Suboptimal glycemic control in individuals with diabetes leads to chronic complications and increases mortality. Therefore, efficient glucose control is essential for the prevention of life threatening complications of the disease. The increasing need of aggressive diabetes treatment has led to the improvement of insulin therapy and its implementation techniques. CSII and MDI regimens are the t...