In the 16th century, the astronomer Nicolas Coper-nicus created a new paradigm when he described the rotation of the earth on its axis and its orbit of the sun. In De Revolutionibus, he described this new concept as " A fundamental change in the way of thinking or looking at a work or concept. " 1 Revolutionary concepts do not often arise in medicine. However, they are fundamental to its progre...

REPLY: In the letter of Chmielewski and Snyder-Mackler, the authors pointed out that the clinical classification scheme used in their studies is not comparable to ours to separate anterior cruciate ligament (ACL) patients without “giving-way symptoms” (copers) from ACL patients with giving-way symptoms (noncopers). In contrast to their comprehensive screening protocol that included issues of di...

We present spectroscopic and photometric observations of the recent peculiar outburst of V838 Mon, carried out at Rozhen and Toru´n observatories. Our data cover a period of three months beginning just before the second eruption. The evolution of the outburst is divided into four phases. The changes of particular spectral features for each of these phases are shortly discussed. V838 Mon is one ...

Programs such as Bacon, Abacus, Coper, Kepler and others are designed to find functional relationships of scientific significance in numerical data without relying on the deep domain knowledge scientists normally bring to bear in analytic work. Whether these systems actually perform as intended is an open question, however. To date, they have been supported only by anecdotal evidence-reports th...