نتایج جستجو برای: copy number variations

تعداد نتایج: 1355626  

2014
Qian Wan Ranadip Pal

We consider the problem of predicting sensitivity of cancer cell lines to new drugs based on supervised learning on genomic profiles. The genetic and epigenetic characterization of a cell line provides observations on various aspects of regulation including DNA copy number variations, gene expression, DNA methylation and protein abundance. To extract relevant information from the various data t...

Journal: :Bioinformation 2007
Lucía Conde David Montaner Jordi Burguet-Castell Joaquín Tárraga Fátima Al-Shahrour Joaquín Dopazo

Contrarily to the traditional view in which only one or a few key genes were supposed to be the causative factors of diseases, we discuss the importance of considering groups of functionally related genes in the study of pathologies characterised by chromosomal copy number alterations. Recent observations have reported the existence of regions in higher eukaryotic chromosomes (including humans)...

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